{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:21:29Z","timestamp":1767925289110,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:00:00Z","timestamp":1414022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The distinction between constitutional delay of growth and puberty (<jats:styled-content style=\"fixed-case\">CDGP<\/jats:styled-content>) and isolated hypogonadotropic hypogonadism (<jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content>) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist test (triptorelin 0\u00b71\u00a0mg) in comparison with inhibin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> alone or in combination with basal <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> for the diagnosis of <jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and measurements<\/jats:title><jats:p>Ninety\u2010seven prepubertal males aged 13\u00b77\u201317\u00b75\u00a0year, with testicular volumes \u22644\u00a0ml, were examined every 6\u00a0months. <jats:styled-content style=\"fixed-case\">CDGP<\/jats:styled-content> was defined by a testicular volume \u22658\u00a0ml after 18\u00a0months, and <jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content> was defined by a testicular volume &lt;5\u00a0ml after 24\u00a0months follow\u2010up. Inhibin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> concentrations were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> concentrations were measured by <jats:styled-content style=\"fixed-case\">CLIA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At follow\u2010up, the cohort comprised 52 boys with CDGP and nine with IHH. The other patients were lost for follow\u2010up (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), had not reached follow\u2010up yet (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) or did not reach a definite testicular volume (<jats:italic>n<\/jats:italic>\u00a0=\u00a06). Basal LH &lt;0\u00b73\u00a0IU\/l, stimulated LH (4\u00a0h) &lt;5\u00b73\u00a0IU\/l or inhibin B &lt;111\u00a0pg\/ml had 100% sensitivity for IHH. Only LH (4\u00a0h) &lt;5\u00b73\u00a0IU\/l had a specificity of 100%, and the specificities of basal LH &lt;0\u00b73\u00a0IU\/l (88%) or inhibin B\u00a0&lt;110\u00a0pg\/ml (92%) were lower. The combination of LH &lt;0\u00b73\u00a0IU\/l with inhibin B &lt;111\u00a0pg\/ml increased the specificity to 98\u00b71%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> response 4\u00a0h after <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist stimulation has an excellent accuracy for the diagnosis of <jats:styled-content style=\"fixed-case\">IHH<\/jats:styled-content> in prepubertal boys with delayed puberty. However, the measurement of inhibin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> and basal <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> in combination is a valid, reliable and less\u2010invasive alternative test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12613","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T11:36:12Z","timestamp":1410348972000},"page":"100-105","source":"Crossref","is-referenced-by-count":58,"title":["Inhibin <scp>B<\/scp> plus <scp>LH <\/scp><i>vs<\/i> Gn<scp>RH<\/scp> agonist test for distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism in boys"],"prefix":"10.1111","volume":"82","author":[{"given":"Gerhard","family":"Binder","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology University Children's Hospital Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology University Children's Hospital Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Blumenstock","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Applied Biometry University of Tuebingen Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Braun","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology University Children's Hospital Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1109290"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"110","article-title":"Genetics of male hypogonadotropic hypogonadism","volume":"10","author":"Naoko S.","year":"2012","journal-title":"Pediatric Endocrinology Reviews"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8395"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/clinchem\/39.9.1815","article-title":"Development of third\u2010generation immunochemiluminometric assays of follitropin and lutropin and clinical application in determining pediatric reference ranges","volume":"39","author":"Pandian M.R.","year":"1993","journal-title":"Clinical Chemistry"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.8.1381"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1598"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2002.15.5.589"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1535"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.08.045"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2732"},{"key":"e_1_2_7_12_1","first-page":"494","article-title":"GnRH and HCG tests are both necessary in differential diagnosis of male delayed puberty","volume":"139","author":"Dunkel L.","year":"1985","journal-title":"American Journal of Diseases of Children"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70406-X"},{"key":"e_1_2_7_14_1","first-page":"23","article-title":"The human chorionic gonadotropin test is more powerful than the gonadotropin\u2010releasing hormone agonist test to discriminate male isolated hypogonadotropic hypogonadism from constitutional delay in puberty","volume":"149","author":"Degros V.","year":"2003","journal-title":"Clinical Endocrinology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.10.2980"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1996.9.1.9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01520.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0302"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01855"},{"key":"e_1_2_7_20_1","first-page":"61","article-title":"Testicular volume during adolescence. 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