{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:11:40Z","timestamp":1762161100713},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T00:00:00Z","timestamp":1415145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate revised criteria for polycystic ovarian morphology (<jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content>) in the diagnosis of polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) in anovulatory infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">WHO G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> anovulatory infertile women (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Clinical, sonographic and endocrine parameters, including anti\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u00fcllerian hormone (<jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>otterdam criteria for <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content> (antral follicle count (<jats:styled-content style=\"fixed-case\">AFC<\/jats:styled-content>) \u226512 and\/or ovarian volume &gt;10\u00a0ml) were fulfilled in 93% of the women. The <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content> prevalence was 68% when increasing the threshold to <jats:styled-content style=\"fixed-case\">AFC<\/jats:styled-content> &gt;20 and 76% according to an <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\u2010based threshold of &gt;35\u00a0pmol\/l. The most recently proposed <jats:styled-content style=\"fixed-case\">AFC<\/jats:styled-content>\u00a0\u2265\u00a025 threshold reduced the <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content> prevalence to 52% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>39), leaving 48% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>36) without features of <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content>. Comparing the 36 women with non\u2010<jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content> with the 39 women in the <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content> group according to <jats:styled-content style=\"fixed-case\">AFC<\/jats:styled-content>\u00a0\u2265\u00a025, 22% <jats:italic>vs<\/jats:italic> 59% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001) had serum <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>\u00a0&gt;10\u00a0IU\/l, 11% <jats:italic>vs<\/jats:italic> 41% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7003) had an <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> ratio &gt;2 and 19% <jats:italic>vs<\/jats:italic> 41% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b704) had hirsutism and\/or elevated total testosterone, free testosterone, and\/or androstenedione. The non\u2010<jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content> group included significantly more women with secondary infertility. The median <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> in the non\u2010<jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content> group was 47\u00a0pmol\/l, which was twofold lower than in the <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content> group but above the upper limit of normo\u2010ovulatory women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to a revised threshold of 25 follicles, almost half the anovulatory infertile women do not have <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content>. The characteristics of these women may be compatible with hypothalamic anovulation, but according to <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> levels, the ovaries remain multifollicular.<\/jats:p><\/jats:sec><jats:sec><jats:title>Perspectives<\/jats:title><jats:p>A better distinction between hypothalamic amenorrhoea and <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> could improve treatment strategies for anovulatory infertility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12621","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T03:47:34Z","timestamp":1411789654000},"page":"584-591","source":"Crossref","is-referenced-by-count":28,"title":["Revised criteria for <scp>PCOS<\/scp> in <scp>WHO G<\/scp>roup <scp>II<\/scp> anovulatory infertility \u2013 a revival of hypothalamic amenorrhoea?"],"prefix":"10.1111","volume":"82","author":[{"given":"Mette Petri","family":"Lauritsen","sequence":"first","affiliation":[{"name":"The Fertility Clinic Section 4071 Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Pinborg","sequence":"additional","affiliation":[{"name":"The Fertility Clinic Section 4071 Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Department of Obstetrics and Gynaecology The Fertility Clinic Hvidovre Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Loft","sequence":"additional","affiliation":[{"name":"The Fertility Clinic Section 4071 Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen Holm","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Lis","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Fertility Clinic Holb\u00e6k Hospital Holb\u00e6k Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne Rich","family":"Bjerge","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Fertility Clinic Holb\u00e6k Hospital Holb\u00e6k Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Nyboe Andersen","sequence":"additional","affiliation":[{"name":"The Fertility Clinic Section 4071 Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_7_3_1","first-page":"377","volume-title":"Polycystic Ovary Syndrome","author":"Zawadzki J.K.","year":"1992"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0178"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32915-2"},{"key":"e_1_2_7_6_1","unstructured":"WHO Scientific Group. 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