{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:32:25Z","timestamp":1761895945987},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the relationship between beta\u2010cell function and the incretin effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We performed a 180\u2010min hyperglycaemic clamp study with oral glucose administration at 60\u00a0min in Korean subjects with normal glucose tolerance (<jats:styled-content style=\"fixed-case\">NGT<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a09), impaired fasting glucose (<jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a06) and type 2 diabetes mellitus (T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>First\u2010 and second\u2010phase insulin secretions were measured during the first 60\u00a0min. The insulin response to intravenous glucose during the 60\u2010 to 120\u2010min interval (Ins<jats:sub>iv<\/jats:sub>) was calculated using a prediction method. The insulin response to oral glucose (Ins<jats:sub>oral<\/jats:sub>) was calculated by subtracting the Ins<jats:sub>iv<\/jats:sub> from the overall insulin response during the 60\u2010 to 120\u2010min interval (Ins<jats:sub>overall<\/jats:sub>). The incretin effect under the hyperglycaemic clamp condition (<jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content><jats:sub>clamp<\/jats:sub>) was calculated by the equation: 100\u00a0\u00d7\u00a0[(Ins<jats:sub>overall<\/jats:sub> \u2212 Ins<jats:sub>iv<\/jats:sub>)\/Ins<jats:sub>overall<\/jats:sub>].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IE<jats:sub>clamp<\/jats:sub> was comparable among the three groups (46\u00b73\u00a0\u00b1\u00a06\u00b74%, 35\u00b77\u00a0\u00b1\u00a08\u00b78% and 51\u00b74\u00a0\u00b1\u00a07\u00b74% for the NGT, IFG and T2DM group, respectively, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7327) and was not correlated with the first\u2010 and second\u2010phase insulin secretions. However, the Ins<jats:sub>oral<\/jats:sub> (<jats:styled-content style=\"fixed-case\">mU<\/jats:styled-content>\/l\u00a060\u00a0min) was significantly different between the NGT, IFG and T2DM groups (5199\u00a0\u00b1\u00a01185, 2164\u00a0\u00b1\u00a0956 and 1034\u00a0\u00b1\u00a0355, respectively; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7010) and was well correlated with the first\u2010 and second\u2010phase insulin secretions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incretin effect measured by the hyperglycaemic clamp with oral glucose loading was neither correlated with beta\u2010cell function nor different between <jats:styled-content style=\"fixed-case\">NGT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IFG<\/jats:styled-content> and T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> groups in Koreans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12623","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T07:37:15Z","timestamp":1412062635000},"page":"59-66","source":"Crossref","is-referenced-by-count":5,"title":["Correlation of the incretin effect with first\u2010 and second\u2010phase insulin secretions in Koreans with various glucose tolerance statuses"],"prefix":"10.1111","volume":"83","author":[{"given":"Tae Jung","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Min","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of 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