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In adult men, enteral glucose ingestion results in acute lowering of serum testosterone levels; however, this has not been studied in adolescents. We aimed to examine the acute effect of a glucose\/protein beverage on serum T concentration changes in obese peripubertal males. A second objective was to determine whether change in T concentration was related to appetite hormone levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Twenty\u2010three overweight and obese males aged 8\u201317 in pre\u2010early (Tanner stage 1\u20132) and mid\u2010late (Tanner stage 3\u20135) puberty were included in this cross\u2010sectional study at the Clinical investigative unit at the Hospital for Sick Children. Participants consumed a beverage containing glucose and protein, and blood samples measuring pubertal hormones, ghrelin and glucagon\u2010like peptide\u20101 (<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101) were taken over 60\u00a0min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across pubertal stages, there was a significant decrease in T levels in adolescent boys (\u221218\u00b76\u00a0\u00b1\u00a03\u00b71%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) with no proportional differences between pre\u2010early and mid\u2010late puberty (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b709). Decrease in T was associated with a decrease in <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b752, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702), and fasting T was inversely correlated with fasting ghrelin (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b751, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703) with no correlation with <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intake of a mixed glucose\/protein beverage acutely decreases T levels in overweight and obese peripubertal boys. A potential mechanism for this decrease may be secondary to an acute decrease in <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>, but this requires further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12630","type":"journal-article","created":{"date-parts":[[2014,10,11]],"date-time":"2014-10-11T22:51:49Z","timestamp":1413067909000},"page":"332-338","source":"Crossref","is-referenced-by-count":7,"title":["Acute decrease in serum testosterone after a mixed glucose and protein beverage in obese peripubertal boys"],"prefix":"10.1111","volume":"83","author":[{"given":"Alexander","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences Faculty of Medicine University of Toronto Toronto ON Canada"},{"name":"Division of Endocrinology Department of Paediatrics The Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barkha P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Faculty of Medicine University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Vien","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Faculty of Medicine University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian W.","family":"McCrindle","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Paediatrics The Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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