{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:36:59Z","timestamp":1773931019694,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["(intramural)"],"award-info":[{"award-number":["(intramural)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse gender differences in the clinical presentation and recovery of paediatric patients with Cushing's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) after transsphenoidal surgery (<jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content>). Indeed, gender differences between paediatric patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> during presentation, after <jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content> and postoperative recovery have not been adequately studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Data were obtained and retrospectively analysed from clinical reports and biochemical tests at the time of presentation, 5\u20139\u00a0days after <jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content> and at the 6 and 12\u00a0months postoperative follow\u2010up visits to determine hypothalamic\u2013pituitary\u2013adrenal axis (<jats:styled-content style=\"fixed-case\">HPAA<\/jats:styled-content>) recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Data from 102 paediatric patients (48 females, 54 males, mean age 12\u00b79\u00a0\u00b1\u00a03\u00b70) with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> who underwent <jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content> at the National Institute of Health (<jats:styled-content style=\"fixed-case\">NIH<\/jats:styled-content>) Clinical Center between 1997 and 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was equal distribution of paediatric <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> between males and females (53% <jats:italic>vs<\/jats:italic> 47%; <jats:italic>n<\/jats:italic>\u00a0=\u00a0102, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7484). Males were more likely than females to present with higher mean <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> Z\u2010scores (2\u00b72\u00a0\u00b1\u00a00\u00b77 <jats:italic>vs<\/jats:italic> 1\u00b79\u00a0\u00b1\u00a00\u00b76, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70079), lower mean height Z\u2010scores (\u22121\u00b72\u00a0\u00b1\u00a01\u00b73 <jats:italic>vs<\/jats:italic> \u22120\u00b77\u00a0\u00b1\u00a01\u00b71, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70467) and higher median plasma <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> (12\u00b72 <jats:italic>vs<\/jats:italic> 8\u00b75 pmol\/l; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70495). Females did not present more frequently with any single sign or symptom. No significant differences were found between males and females for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> cure rates 5\u20139\u00a0days after <jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content> (87\u00b70% males <jats:italic>vs<\/jats:italic> 87\u00b75% females, <jats:italic>P<\/jats:italic>\u00a0=\u00a01\u00b70), long\u2010term cure rates (86\u00b75% <jats:italic>vs<\/jats:italic> 93\u00b77%; <jats:italic>n<\/jats:italic>\u00a0=\u00a069; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b74374) and <jats:styled-content style=\"fixed-case\">HPAA<\/jats:styled-content> recovery time (11\u00b72\u00a0\u00b1\u00a02\u00b75 <jats:italic>vs<\/jats:italic> 11\u00b77\u00a0\u00b1\u00a02\u00b75\u00a0months; <jats:italic>n<\/jats:italic>\u00a0=\u00a047; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b71992).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Paediatric <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> is found to have equal distribution between males and females, but male patients present with elevated <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and potentially shorter height and higher plasma <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>. There is no significant difference in the cure rate or <jats:styled-content style=\"fixed-case\">HPAA<\/jats:styled-content> recovery time after <jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content> between males and females.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12644","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T12:17:24Z","timestamp":1415708244000},"page":"72-77","source":"Crossref","is-referenced-by-count":43,"title":["A gender\u2010dependent analysis of Cushing's disease in childhood: pre\u2010 and postoperative follow\u2010up"],"prefix":"10.1111","volume":"83","author":[{"given":"Laura G.","family":"Libuit","sequence":"first","affiliation":[{"name":"Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander S.","family":"Karageorgiadis","sequence":"additional","affiliation":[{"name":"Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninet","family":"Sinaii","sequence":"additional","affiliation":[{"name":"Biostatistics and Clinical Epidemiology Service National Institutes of Health Clinical Center Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina M.","family":"Nguyen May","sequence":"additional","affiliation":[{"name":"Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret F.","family":"Keil","sequence":"additional","affiliation":[{"name":"Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya B.","family":"Lodish","sequence":"additional","affiliation":[{"name":"Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine A.","family":"Stratakis","sequence":"additional","affiliation":[{"name":"Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021518"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1542\/peds.56.5.797","article-title":"Hypercortisolism in childhood: shortcomings of conventional diagnostic criteria","volume":"56","author":"Streeten D.H.","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_6_5_1","first-page":"207","article-title":"Growth retardation in Cushing's syndrome","volume":"123","author":"Strickland A.L.","year":"1972","journal-title":"American Journal of Diseases of Children"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01888.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.027"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02822.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.03.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343985"},{"key":"e_1_2_6_11_1","first-page":"318","article-title":"Cushing's disease in children. Findings in 13 cases","volume":"47","author":"McArthur R.G.","year":"1972","journal-title":"Mayo Clinic Proceedings"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031531"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1684"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111245.75752.C6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0302"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031170"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2325"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.065"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3604"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.8.821"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-004-0012-x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.11.007"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1312"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-6-487"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198404053101405"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.10.3196"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.8.2475"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-5-1056"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.10.3196"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236081"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2012-0130"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12644","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:17:47Z","timestamp":1695496667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/cen.12644"],"URL":"https:\/\/doi.org\/10.1111\/cen.12644","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,2]]}}}