{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:29:24Z","timestamp":1776882564520,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Polycystic ovary syndrome (PCOS<\/jats:styled-content>) is associated with cardiovascular risk factors including hypertension, obesity, hyperlipidaemia and glucose intolerance. Several studies demonstrated the link between PCOS<\/jats:styled-content> and an increased risk of cardiovascular disease. Platelets play a crucial role in the development of atherothrombotic disease. Mean platelet volume (MPV<\/jats:styled-content>) is a marker of platelet size that reflects its activity. Research points to a link between prolactin (PRL<\/jats:styled-content>) and platelet activation. The purpose of this study was to investigate whether prolactin levels are associated with MPV<\/jats:styled-content> in women with PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Design<\/jats:title>The research was designed as a cross\u2010sectional study.<\/jats:p><\/jats:sec>Patients<\/jats:title>Participants were divided into three groups\u2010PCOS<\/jats:styled-content> patients with mildly elevated PRL<\/jats:styled-content> levels (n<\/jats:italic>\u00a0=\u00a072), patients with PCOS<\/jats:styled-content> with normal PRL<\/jats:styled-content> levels (n<\/jats:italic>\u00a0=\u00a0207) and healthy controls (n<\/jats:italic>\u00a0=\u00a090). They were body mass index and age\u2010matched and consecutively recruited.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Complete blood counts, serum glucose, prolactin, insulin, lipids, high\u2010sensitivity C\u2010reactive protein and free\u2010testosterone levels were measured.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the three groups, MPV<\/jats:styled-content> levels were higher in women with PCOS<\/jats:styled-content> having mildly elevated PRL<\/jats:styled-content> levels (P<\/jats:italic>\u00a0<\u00a00\u00b7001) and MPV<\/jats:styled-content> was found to be correlated with PRL<\/jats:styled-content> levels (r<\/jats:italic>\u00a0=\u00a00\u00b7387, P<\/jats:italic>\u00a0<\u00a00\u00b7001). Multiple regression analysis showed that PRL<\/jats:styled-content> levels were associated with MPV<\/jats:styled-content> levels (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00\u00b7239, \u03b2\u00a0=\u00a00\u00b7354, P<\/jats:italic>\u00a0<\u00a00\u00b7001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Mean platelet volume levels are significantly increased in women with PCOS<\/jats:styled-content> having mildly elevated PRL<\/jats:styled-content>. Our results suggest that there is a link between prolactin and MPV<\/jats:styled-content> levels. In women with PCOS<\/jats:styled-content>, elevated PRL<\/jats:styled-content> levels may increase the risk of developing atherothrombotic events via the activation of platelets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12647","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T08:53:31Z","timestamp":1414745611000},"page":"747-752","source":"Crossref","is-referenced-by-count":10,"title":["The effect of prolactin levels on MPV in women with PCOS"],"prefix":"10.1111","volume":"82","author":[{"given":"\u00d6zg\u00fcr","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Manisa Merkezefendi State Hospital Inciralti Turkey"},{"name":"Department of Obstetrics and Gynecology Manisa Akhisar State Hospital Inciralti Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Calan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology of Metabolism Department 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Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041536"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2350"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2724"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12068"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8471"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.04.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-29423-5_5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1102-1227"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199603000-00011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1051-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000130512.81212.a2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1724"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100600901590"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2012.710858"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1349"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0017"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39479"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.132100"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490187"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-955090"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.209569"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8085"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-825727"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509283331307"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.121400"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-21-11-1440"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(05)70186-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590701297708"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-814200"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1160\/TH08-12-0801","article-title":"Prolactin 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