{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:53:39Z","timestamp":1788170019619,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The functional significance of basal ganglia calcification <jats:bold>(<\/jats:bold><jats:styled-content style=\"fixed-case\">BGC<\/jats:styled-content>) in idiopathic hypoparathyroidism (<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>) is not clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of <jats:styled-content style=\"fixed-case\">BGC<\/jats:styled-content> on glucose metabolism and dopaminergic function in <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> and <jats:sup>99m<\/jats:sup>Tc\u2010<jats:styled-content style=\"fixed-case\">TRODAT<\/jats:styled-content>\u20101 nuclear imaging were performed in 35 IH patients with (<jats:italic>n<\/jats:italic>\u00a0=\u00a026) and without (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) <jats:styled-content style=\"fixed-case\">BGC<\/jats:styled-content>. Controls were subjects without hypoparathyroidism or <jats:styled-content style=\"fixed-case\">BGC<\/jats:styled-content> (nine for <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> and 12 for <jats:sup>99m<\/jats:sup>Tc\u2010<jats:styled-content style=\"fixed-case\">TRODAT<\/jats:styled-content>\u20101). Relationship of the glucose metabolism and dopaminergic function was assessed with the neuropsychological and biochemical abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> uptake in <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> patients with calcification at caudate and striatum was less than that of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> patients without calcification (1\u00b706\u00a0\u00b1\u00a00\u00b713 <jats:italic>vs<\/jats:italic> 1\u00b724\u00a0\u00b1\u00a00\u00b709, <jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;0\u00b70001 and 1\u00b706\u00a0\u00b1\u00a00\u00b709 <jats:italic>vs<\/jats:italic> 1\u00b714\u00a0\u00b1\u00a00\u00b708, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703, respectively). <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> uptake did not correlate with neuropsychological dysfunctions. <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> uptake in <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">BGC<\/jats:styled-content> was significantly lower than that of controls. The mean <jats:sup>99m<\/jats:sup>Tc\u2010<jats:styled-content style=\"fixed-case\">TRODAT<\/jats:styled-content>\u20101 uptake at basal ganglia was comparable between <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> with and without <jats:styled-content style=\"fixed-case\">BGC<\/jats:styled-content> and between <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">BGC<\/jats:styled-content> and controls. Serum calcium\u2013phosphorus ratio maintained by the patients correlated with <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> uptake at striatum (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b757, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001). For every 0\u00b71 unit reduction in calcium\u2013phosphorus ratio, <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> uptake decreased by 2\u00b75\u00a0\u00b1\u00a00\u00b768% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BGC<\/jats:styled-content> was associated with modest reduction (15%) in <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> uptake at basal ganglia in <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> but did not affect dopaminergic function. <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> uptake did not correlate with neuropsychological dysfunctions. Interestingly, chronic hypocalcaemia\u2013hyperphosphataemia also contributed to reduction in <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\">F\u2010FDG<\/jats:styled-content> uptake which was independent of <jats:styled-content style=\"fixed-case\">BGC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12649","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T15:04:52Z","timestamp":1415027092000},"page":"563-571","source":"Crossref","is-referenced-by-count":4,"title":["Effect of basal ganglia calcification on its glucose metabolism and dopaminergic function in idiopathic hypoparathyroidism"],"prefix":"10.1111","volume":"83","author":[{"given":"Sagar","family":"Modi","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetanjali","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Shekhar","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnubhatla","family":"Sreenivas","sequence":"additional","affiliation":[{"name":"Department of Biostatistics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suparna","family":"Kailash","sequence":"additional","affiliation":[{"name":"Department of Psychiatry All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Sagar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04353.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.7.779"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3863"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.1.20"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40527-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0946"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2158"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0075"},{"key":"e_1_2_8_10_1","first-page":"2069","article-title":"Biodistribution and dosimetry of TRODAT\u20101: a technetium\u201099m tropane for imaging dopamine transporters","volume":"39","author":"Mozley P.D.","year":"1998","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10592"},{"key":"e_1_2_8_12_1","first-page":"393","article-title":"Sensitivity and specificity of 99mTc\u2010TRODAT\u20101 SPECT imaging in differentiating patients with idiopathic Parkinson's disease from healthy subjects","volume":"45","author":"Weng Y.H.","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_8_13_1","unstructured":"Nazar A.H. 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