{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:12:54Z","timestamp":1757704374041,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["90700308"],"award-info":[{"award-number":["90700308"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Netherlands Ministry of Health Welfare and Sports"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Osteocalcin is a well\u2010known marker of bone formation. Recently, mice lacking osteocalcin or its receptor were reported to be subfertile with low testosterone and high luteinizing hormone concentrations. In parallel, in humans, a loss\u2010of\u2010function mutation of the osteocalcin receptor was associated with hypergonadotropic hypogonadism. This suggests that osteocalcin is necessary for normal pituitary\u2010gonadal axis function. Our objective was to determine the association between physiological variations in osteocalcin and the pituitary\u2010gonadal axis in older men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>Data were used from the Longitudinal Aging Study Amsterdam (<jats:styled-content style=\"fixed-case\">LASA<\/jats:styled-content>), an ongoing cohort study in a representative sample of the older Dutch population (65\u201388\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Serum levels of total (T), free (<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>) and bioavailable (bioT) testosterone, luteinizing hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>) and osteocalcin were determined. Data were analysed using linear regression analyses and adjusted for age, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, 25\u2010hydroxyvitamin D, parathyroid hormone and vitamin K antagonist use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 614 men participated in the study. The median age was 75\u00b74 (69\u00b78\u201381\u00b72) years, and the median osteocalcin level was 1\u00b78 (1\u00b73\u20132\u00b74) nmol\/l. Serum osteocalcin was inversely associated with FT (adjusted B\u00a0=\u00a0\u22120\u00b722\u00a0\u00b1\u00a00\u00b709\u00a0ng\/dl, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7012) and bioT (adjusted B\u00a0=\u00a0\u22120\u00b726\u00a0\u00b1\u00a00\u00b708\u00a0nmol\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701), but not with total T. Furthermore, osteocalcin was positively associated with LH (adjusted B\u00a0=\u00a00\u00b709\u00a0\u00b1\u00a00\u00b703 U\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum osteocalcin was negatively associated with free and bioavailable testosterone and positively with luteinizing hormone levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12660","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T10:57:29Z","timestamp":1415357849000},"page":"753-759","source":"Crossref","is-referenced-by-count":9,"title":["Osteocalcin and the pituitary\u2010gonadal axis in older men: a population\u2010based study"],"prefix":"10.1111","volume":"82","author":[{"given":"E.J.","family":"Limonard","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.M.","family":"van Schoor","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics EMGO Institute for Health and Care Research VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.T.","family":"de Jongh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrinology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lips","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrinology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Fliers","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.H.","family":"Bisschop","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.23.3.0465"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.11.097"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2005.07.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1989.69.3.990"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24278"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65952"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46401-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-2-432"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1210\/endo.143.8.8928","article-title":"Minireview: genetic models for the study of gonadotropin actions","volume":"143","author":"Burns K.H.","year":"2002","journal-title":"Endocrinology"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2012.00044.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-013-9730-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2013.00095.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.421"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2017-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1805"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq219"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.6079"},{"key":"e_1_2_7_21_1","unstructured":"Garretsen H.F.L.Probleemdrinken: prevalentiebepaling beinvloedende factoren en preventiemogelijkheden: theoretische overwegingen en onderzoek in Rotterdam Lisse The Netherlands: Swets en Zeitlinger; 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