{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:04:18Z","timestamp":1777611858121,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T00:00:00Z","timestamp":1419552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008793","name":"Universidad del Rosario","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008793","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Summary<\/jats:title>Objectives<\/jats:title>To determine the prevalence and the predictive factors of autoimmune hypothyroidism (AH<\/jats:styled-content>) within a systemic lupus erythematosus (SLE<\/jats:styled-content>) cohort and to analyse the current information concerning the prevalence and impact of autoimmune thyroid disease (AITD<\/jats:styled-content>) and thyroid autoimmunity in patients with SLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 376 patients with SLE<\/jats:styled-content> were assessed for the presence of the following: (i) confirmed AH<\/jats:styled-content>, (ii) positive thy\u2010roperoxidase\/thyroglobulin antibodies [TPOA<\/jats:styled-content>b\/TgAb] without hypothyroidism, (iii) nonautoimmune hypothyroidism and (iv) SLE<\/jats:styled-content> patients with neither. Multivariate analysis and a classification and regression tree model were used to analyse data. The current information was discussed through a systematic literature review (SLR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>In our cohort, the prevalence of confirmed AH<\/jats:styled-content> was 12%. However, in euthyroid patients with SLE<\/jats:styled-content>, TPOA<\/jats:styled-content>b and TgAb were observed in 21% and 10%, respectively. Patients with confirmed AH<\/jats:styled-content> were significantly older and had later age at onset of the disease. Smoking (adjusted odds ratio (AOR<\/jats:styled-content>) 6\u00b793, 95% CI<\/jats:styled-content> 1\u00b798\u201328\u00b754, P\u00a0=\u00a0<\/jats:italic>0\u00b7004), Sj\u00f6gren's Syndrome (SS<\/jats:styled-content>) (AOR<\/jats:styled-content> 23\u00b72, 95% CI<\/jats:styled-content> 1\u00b789\u2013359\u00b753, P\u00a0=\u00a0<\/jats:italic>0\u00b7015) and positivity for anticyclic citrullinated peptide (anti\u2010CCP<\/jats:styled-content>) (AOR<\/jats:styled-content> 10\u00b735, 95% CI<\/jats:styled-content> 1\u00b704\u2013121\u00b726, P\u00a0=\u00a0<\/jats:italic>0\u00b7047) were associated with AH<\/jats:styled-content>\u2010SLE<\/jats:styled-content>, regardless of gender and duration of the disease. Smoking and SS<\/jats:styled-content> were confirmed as predictors of AH<\/jats:styled-content>\u2010SLE<\/jats:styled-content>. In the SLR<\/jats:styled-content>, the prevalence of AITD<\/jats:styled-content> ranged from 1% to 60%. The factors associated with this polyautoimmunity were female gender, older age, smoking, certain autoantibodies, SS<\/jats:styled-content>, and cutaneous and articular involvement.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>AITD<\/jats:styled-content> is frequent in SLE<\/jats:styled-content> and does not affect the severity of SLE<\/jats:styled-content>. Identified risk factors will assist clinicians in the search for AITD<\/jats:styled-content>. Our results encourage smoke\u2010free policies in patients with SLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12662","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T14:41:53Z","timestamp":1415457713000},"page":"943-950","source":"Crossref","is-referenced-by-count":41,"title":["Autoimmune thyroid disease in C<\/scp>olombian patients with systemic lupus erythematosus"],"prefix":"10.1111","volume":"83","author":[{"given":"Juan\u2010Sebastian","family":"Franco","sequence":"first","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"},{"name":"Mederi Hospital Universitario Mayor Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Amaya\u2010Amaya","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"},{"name":"Mederi Hospital Universitario Mayor Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Molano\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Caro\u2010Moreno","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Rodr\u00edguez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeny","family":"Acosta\u2010Ampudia","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n D.","family":"Mantilla","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"},{"name":"Mederi Hospital Universitario Mayor Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Rojas\u2010Villarraga","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"},{"name":"Mederi Hospital Universitario Mayor Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan\u2010Manuel","family":"Anaya","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"},{"name":"Mederi Hospital Universitario Mayor Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"537","volume-title":"Autoimmunity: From Bench to Bedside","author":"Franco J.S.","year":"2013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834ddb27"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021194"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8182"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/274323"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.10.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.12.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8302-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120022"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.02.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/794383"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_8_15_1","volume-title":"The Oxford 2011 Levels of Evidence","author":"OCEBM Levels of Evidence Working Group","year":"2011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1970.tb63325.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1969.11697269"},{"key":"e_1_2_8_18_1","first-page":"407","article-title":"Antithyroid antibodies in the course of exrathyroid diseases","volume":"5","author":"Jaffiol C.","year":"1964","journal-title":"Revue Fran\u00e7aise d'Endocrinologie Clinique, Nutrition, et M\u00e9tabolisme"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)92982-8"},{"key":"e_1_2_8_20_1","first-page":"2674","article-title":"Hashimoto thyroiditis, lupus erythematosus and thrombopenic purpura: autoimmune combination","volume":"40","author":"Moretti G.","year":"1964","journal-title":"La Semaine des H\u00f4pitaux"},{"key":"e_1_2_8_21_1","first-page":"1571","article-title":"Detection of immune globulin and autoantibodies in autoimmune diseases, with special reference to SLE and Hashimoto's diseases","volume":"22","author":"Ofumi T.","year":"1968","journal-title":"Naika"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.013"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072503321086962"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324442"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1390290"},{"key":"e_1_2_8_27_1","first-page":"1193","article-title":"A prospective evaluation of antithyroid antibody prevalence in 100 patients with systemic lupus erythematosus","volume":"18","author":"Vianna J.L.","year":"1991","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.4.349-a"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055103"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31819dbe4c"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.102962"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2889-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.06.003"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04455.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/864907"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2004.11.003"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12662","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12662","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.12662","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:57:51Z","timestamp":1692406671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,26]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/cen.12662"],"URL":"https:\/\/doi.org\/10.1111\/cen.12662","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,26]]}}}