{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:11:23Z","timestamp":1755925883605},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A physiological increase in androgen levels occurs during adolescence. Measuring androgen concentrations is the best method to distinguish normal evolution processes from hyperandrogenic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The increase in circulating androgens during puberty is inversely associated with insulin sensitivity in normal weight girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess circulating levels of ovarian androgens and anti\u2010M\u00fcllerian hormone (<jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>) at baseline and after Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> analogue (Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\u2010a) stimulation in normal pubertal girls across different Tanner stages. We also studied the association between this response and insulin sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective study of healthy girls (6\u201312\u00a0years) from the local community (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>63).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tanner I (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>23) subjects were assessed cross\u2010sectionally, and Tanner <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> girls (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>40) were evaluated every 6\u00a0months until they reached Tanner V. Early morning dehydroepiandrosterone sulphate (<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>\u2010S), <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>, sex hormone\u2010binding globulin (<jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>), androstenedione, glucose and insulin levels were measured. A Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\u2010a test (500\u00a0\u03bcg\/m<jats:sup>2<\/jats:sup>; sc) and oral glucose intolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) were performed. Differences throughout puberty were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Basal and\/or stimulated Testosterone DHEA\u2010S and 17\u2010hydroxyprogesterone (17<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>) were inversely associated with insulin sensitivity (<jats:styled-content style=\"fixed-case\">WIBSI<\/jats:styled-content>) from the beginning of puberty, whereas androstenedione was directly associated with gonadotrophins. <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> was inversely associated with basal and stimulated gonadotrophins and directly with insulin area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) only in the early stages of puberty. 17<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content> and testosterone responsiveness increased significantly during puberty in all subjects, whereas testosterone levels changed less consistently. This pattern of ovarian\u2010steroidogenic response was most evident during mid\u2010 and late puberty. Moreover, during late puberty only, basal 17<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>, testosterone and <jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>\u2010S were positively associated with gonadotrophins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In normal nonobese girls born appropriate for gestational age, androgen synthesis was associated with insulin sensitivity in early puberty and with <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> only in late puberty.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12690","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T17:17:06Z","timestamp":1418145426000},"page":"205-211","source":"Crossref","is-referenced-by-count":1,"title":["Leuprolide acetate\u2010stimulated androgen response during female puberty"],"prefix":"10.1111","volume":"83","author":[{"given":"Mar\u00eda Isabel","family":"Hernandez","sequence":"first","affiliation":[{"name":"Institute of Maternal and Child Research Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Martinez\u2010Aguayo","sequence":"additional","affiliation":[{"name":"Paediatrics Division Faculty of Medicine Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Cavada","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Chile and University of los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Avila","sequence":"additional","affiliation":[{"name":"Institute of Maternal and Child Research Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German","family":"I\u00f1iguez","sequence":"additional","affiliation":[{"name":"Institute of Maternal and Child Research Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Mericq","sequence":"additional","affiliation":[{"name":"Institute of Maternal and Child Research Faculty of Medicine University of Chile Santiago 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