{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:20:23Z","timestamp":1784114423765,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We are aware of no study examining the effects of selenium supplementation on metabolic profiles of patients with polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>). This study was conducted to evaluate the effects of selenium supplementation on glucose homeostasis parameters and lipid concentrations in women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, patients and measurements<\/jats:title><jats:p>This randomized, double\u2010blind, placebo\u2010controlled trial was conducted among 70 women diagnosed with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and aged 18\u201340\u00a0years old. Participants were randomly divided into two groups to receive 200\u00a0\u03bcg per day selenium supplements (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>35) or placebo (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>35) for 8\u00a0weeks. Fasting blood samples were taken at baseline and after 8\u00a0weeks intervention to quantify glucose, insulin and lipid concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 8\u00a0weeks of intervention, subjects who received selenium supplements had significantly decreased serum insulin levels (\u221229\u00b783\u00a0\u00b1\u00a047\u00b729 <jats:italic>vs<\/jats:italic> +9\u00b707\u00a0\u00b1\u00a077\u00b712 pmol\/l, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7013), homeostasis model of assessment\u2010insulin resistance (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) (\u22121\u00b715\u00a0\u00b1\u00a01\u00b781 <jats:italic>vs<\/jats:italic> +0\u00b742\u00a0\u00b1\u00a03\u00b709, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7011), homeostatic model assessment\u2010beta\u2010cell function (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010B) (\u221219\u00b706\u00a0\u00b1\u00a030\u00b795 <jats:italic>vs<\/jats:italic> +4\u00b755\u00a0\u00b1\u00a047\u00b799, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7017) and increased quantitative insulin sensitivity check index (<jats:styled-content style=\"fixed-case\">QUICKI<\/jats:styled-content>) (+0\u00b703\u00a0\u00b1\u00a00\u00b704 <jats:italic>vs<\/jats:italic> +0\u00b70009\u00a0\u00b1\u00a00\u00b705, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7032) compared with placebo. In addition, supplementation with selenium resulted in a significant reduction in serum triglycerides (\u22120\u00b714\u00a0\u00b1\u00a00\u00b755 <jats:italic>vs<\/jats:italic> +0\u00b711\u00a0\u00b1\u00a00\u00b730\u00a0mmol\/l, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7025) and <jats:styled-content style=\"fixed-case\">VLDL<\/jats:styled-content>\u2010C concentrations (\u22120\u00b703\u00a0\u00b1\u00a00\u00b711 <jats:italic>vs<\/jats:italic> +0\u00b702\u00a0\u00b1\u00a00\u00b706\u00a0mmol\/l, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7025) compared with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, 200 microgram per day selenium supplementation for 8\u00a0weeks among <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women had beneficial effects on insulin metabolism parameters, triglycerides and <jats:styled-content style=\"fixed-case\">VLDL<\/jats:styled-content>\u2010C levels; however, it did not affect <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content> and other lipid profiles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12699","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T05:53:26Z","timestamp":1418709206000},"page":"885-891","source":"Crossref","is-referenced-by-count":82,"title":["Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"82","author":[{"given":"Mehri","family":"Jamilian","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics School of Medicine Arak University of Medical Sciences Arak I.R. 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