{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:08:01Z","timestamp":1762506481043},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T00:00:00Z","timestamp":1422921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As renin and aldosterone levels vary during the menstrual cycle, and are critical criteria for interpretation of aldosterone suppression tests to confirm or exclude primary aldosteronism, outcome of testing may vary depending on the menstrual cycle phase. We assessed the effect of timing within the menstrual cycle on levels of renin, aldosterone and female sex steroids during fludrocortisone suppression testing (<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 22 women undergoing <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> who experienced regular menstrual cycles, renin (measured as both plasma renin activity and direct renin concentration), aldosterone (mass spectrometry) and cortisol, progesterone, oestradiol, <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> (immunoassay) levels were compared, relative to phase of cycle. Aldosterone levels were compared to those in age\u2010matched males undergoing <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Progesterone (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001) and aldosterone (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7006) levels were higher in nine women (after one of 10 was excluded with anovulatory cycle) studied during the luteal phase than in the 12 studied during the follicular phase. All studied during the luteal phase had positive <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>, and all three with negative <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> were studied during the follicular phase. There were no significant differences in other parameters measured except <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>, which was higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702) during the follicular phase. Aldosterone was higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701) in women studied in the luteal (but not follicular) phase compared to men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The menstrual cycle may affect the outcome of <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> and other suppression testing used to diagnose primary aldosteronism. Larger patient numbers and preferably restudy of the same patient in both phases should clarify this and determine the optimum time in the cycle for testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12705","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:23:58Z","timestamp":1418988238000},"page":"303-307","source":"Crossref","is-referenced-by-count":23,"title":["Should aldosterone suppression tests be conducted during a particular phase of the menstrual cycle, and, if so, which phase? Results of a preliminary study"],"prefix":"10.1111","volume":"83","author":[{"given":"Ashraf H.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Ward","sequence":"additional","affiliation":[{"name":"Sullivan &amp; Nicolaides Pathology Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wolley","sequence":"additional","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Kogovsek","sequence":"additional","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stowasser","sequence":"additional","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-690X(03)00050-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1994.tb02519.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00045415-199907000-00012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0626"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1355"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2008.109"},{"key":"e_1_2_6_9_1","first-page":"318","article-title":"LH, progesterone, and TSH can stimulate aldosterone in vitro: a study on normal adrenal cortex and aldosterone producing adenoma","volume":"46","author":"Nicolini G.","year":"2014","journal-title":"Hormone and Metabolic Research"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1154"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833266e3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(96)00007-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200402000-00006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.068502"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.11.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.116004"},{"key":"e_1_2_6_18_1","first-page":"39","article-title":"Laboratory investigation of primary aldosteronism","volume":"31","author":"Stowasser M.","year":"2010","journal-title":"The Clinical biochemist. 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