{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:09:35Z","timestamp":1768968575613,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the prevalence of parathyroid carcinoma (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>) in patients with multiple endocrine neoplasia type 1 (<jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1) and review of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHP<\/jats:styled-content>) is the most common manifestation of <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1. The occurrence of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1 is rare and the literature regarding the clinical manifestations \u2013 including the prevalence of the disease \u2013 is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Context<\/jats:title><jats:p>Single tertiary care centre experience from 1977 to 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Electronic search of the medical records to identify a cohort of patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1. Literature review based on current case reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Single case of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in a cohort of 348 patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1. Ten cases of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1 reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurement<\/jats:title><jats:p>Clinical features of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in 348 patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1 was found to be 0\u00b728% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0\u20131\u00b74%). Based on the current published cases of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1, 54\u00b75% were women, mean age at diagnosis was 48\u00b73\u00a0years, and the serum <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> concentrations at least four times the upper limit of the reference range in 73% of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content> 1 is rare with a prevalence of 0\u00b728%, and the clinical features are similar to <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in patients without <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12714","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T07:23:22Z","timestamp":1420010602000},"page":"244-249","source":"Crossref","is-referenced-by-count":40,"title":["Prevalence of parathyroid carcinoma in 348 patients with multiple endocrine neoplasia type 1 \u2013 case report and review of the literature"],"prefix":"10.1111","volume":"84","author":[{"given":"Naykky","family":"Singh Ospina","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism and Nutrition Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Sebo","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery Department of Surgery Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart L.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism and Nutrition Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"William F.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism and Nutrition Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1230"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4065\/77.1.87"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.10.005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031237"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2003.01168.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.9.657"},{"key":"e_1_2_6_8_1","first-page":"288","article-title":"Pluriglandular syndrome. 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