{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:26:26Z","timestamp":1765545986740},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear whether the rate of vitamin D deficiency in paediatric cancer survivors is higher than in the background population, and whether this is of pathological significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> was measured in a previously studied group of 208 survivors (<jats:italic>n<\/jats:italic>\u00a0=\u00a0108 paediatric 5\u201317\u00a0years, <jats:italic>n<\/jats:italic>\u00a0=\u00a099 adults 18\u201339\u00a0years) and compared with paediatric (5\u201317\u00a0years; <jats:italic>n<\/jats:italic>\u00a0=\u00a0132) and adult controls (25\u201335\u00a0years; <jats:italic>n<\/jats:italic>\u00a0=\u00a01393 from the AusDiab cohort) adjusted for age and gender. Relationships with treatment factors (irradiation, bone marrow transplantation and intensity of treatment) along with overweight\/obesity (defined by <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), abdominal adiposity (waist:height ratio &gt;0\u00b75) and hyperinsulinism or abnormal glucose tolerance (<jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">aGT<\/jats:styled-content>) were sought.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> concentrations were similar in paediatric survivors compared with controls (64\u00b73\u00a0\u00b1\u00a021\u00b76\u00a0nmol\/l <jats:italic>vs<\/jats:italic> 66\u00b73\u00a0\u00b1 22\u00b78\u00a0nmol\/l), with no effect of age or gender. Adjusted for gender, rates of 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> deficiency (&lt;50\u00a0nmol\/l) were higher in adult survivors compared with AusDiab controls (42\u00b74% <jats:italic>vs<\/jats:italic> 20\u00b78%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Apart from time since diagnosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703), no relationship with treatment factors was detected. In multivariate regression analysis, abdominal adiposity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001), but not overweight\/obesity by <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> status nor <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">aGT<\/jats:styled-content>, was associated with significantly lower 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adult survivors are at increased risk of abnormalities in vitamin D compared to the background population, probably reflecting longer time since diagnosis. Like others, we have not identified any contributory treatment\u2010related factors. Vitamin D deficiency does not appear to be associated with the development of abnormal glucose tolerance in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12721","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T10:53:35Z","timestamp":1421664815000},"page":"657-662","source":"Crossref","is-referenced-by-count":11,"title":["The prevalence of Vitamin D deficiency is higher in adult survivors of childhood cancer"],"prefix":"10.1111","volume":"82","author":[{"given":"Kristen A.","family":"Neville","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sydney Children's Hospital Sydney NSW Australia"},{"name":"School of Women's &amp; Children's Health University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan L.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sydney Children's Hospital Sydney NSW Australia"},{"name":"School of Women's &amp; Children's Health University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Cohn","sequence":"additional","affiliation":[{"name":"School of Women's &amp; Children's Health University of New South Wales Sydney NSW Australia"},{"name":"Kid's Cancer Centre Sydney Children's Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T.","family":"Cowell","sequence":"additional","affiliation":[{"name":"Kids Research Institute The Children's Hospital Westmead Sydney NSW Australia"},{"name":"Faculty of Medicine University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"White","sequence":"additional","affiliation":[{"name":"School of Women's &amp; Children's Health University of New South Wales Sydney NSW Australia"},{"name":"SEALS Clinical Chemistry &amp; Endocrinology Prince of Wales Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0051"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.162.6.513"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511003527"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.860"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04320.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.11592"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10301"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21406"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24403"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.326"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24349"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22949"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-10-0002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1454"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-0243"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1000"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0128"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(02)00025-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23320"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.51"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899109147933"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.9.5143"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1773"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.604"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.06.003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.08.023"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.690"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.26"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa060185"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12721","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:23:48Z","timestamp":1695482628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,12]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/cen.12721"],"URL":"https:\/\/doi.org\/10.1111\/cen.12721","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,12]]}}}