{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:46:41Z","timestamp":1695620801852},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Samsung Biomedical Research Institute grant","award":["GL1B32111"],"award-info":[{"award-number":["GL1B32111"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to evaluate an association between testosterone, sex hormone\u2010binding globulin and body composition as well as the influence of genetic and environmental factors on the association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Community\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>One thousand and eighty\u2010three <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orean men including 144 pairs of monozygotic twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>Levels of serum total testosterone (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>) and sex hormone\u2010binding globulin (<jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>) were measured by chemiluminescence immunoassay, and free testosterone (c<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>) was calculated using <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ermeulen's method. Detailed body composition was measured using dual\u2010energy <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray absorptiometry. We performed linear mixed regression analysis with consideration of familial correlations and covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Each 1\u2010<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> increase in age\u2010adjusted levels of <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>, c<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content> was associated with lower levels of adiposity measures and absolute measures of lean body mass. On the other hand, percentage total lean mass increased with increasing levels of <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>, c<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b705). Bivariate variance\u2010component analyses revealed that most body composition measures had a significant inverse unique environmental correlation with both <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>, and a significant genetic correlation with <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>. A co\u2010twin control study in monozygotic twins showed that within\u2010pair differences in adiposity measures were inversely associated with within\u2010pair differences in the levels of <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>, while within\u2010pair differences in lean mass were inversely associated with within\u2010pair differences in the levels of <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The significant associations of body composition with testosterone and <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content> were influenced by both genetic and environmental factors. Further efforts to elucidate related genes and modifiable environmental factors are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12722","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T10:59:14Z","timestamp":1421665154000},"page":"236-245","source":"Crossref","is-referenced-by-count":5,"title":["Genetic and environmental influence on the association between testosterone, sex hormone\u2010binding globulin and body composition in <scp>K<\/scp>orean men"],"prefix":"10.1111","volume":"83","author":[{"given":"Kayoung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Family Medicine Busan Paik Hospital Inje University College of Medicine Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joohon","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Seoul National University Seoul Republic of Korea"},{"name":"Institute of Health 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