{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:58:21Z","timestamp":1761155901553},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>A calcium load to suppress parathyroid hormone (PTH<\/jats:styled-content>) secretion can help to perform the diagnosis in some case of primary hyperparathyroidism (PHPT<\/jats:styled-content>) with atypical presentation. A similar test with calcimimetic, which avoids hypercalcaemia, would be of interest. Our proof of concept study was conducted to compare firstly the results of a single\u2010dose cinacalcet testing with those of the standardized short\u2010time calcium load in healthy control (HC<\/jats:styled-content>) and secondly the results of the single\u2010dose cinacalcet testing in HC<\/jats:styled-content> and in PHPT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twelve HC<\/jats:styled-content>s received in a random order, at a 2\u2010week interval, either 0\u00b733\u00a0mmol\/kg calcium gluconate intravenously for 3\u00a0h, or a single oral dose of 30\u00a0mg or 60\u00a0mg cinacalcet. Twelve PHPT<\/jats:styled-content>s received 30\u00a0mg cinacalcet and twelve other PHPT<\/jats:styled-content>s 60\u00a0mg cinacalcet orally. Calcaemia and serum PTH<\/jats:styled-content> levels were measured basally and then hourly for 6\u00a0h.<\/jats:p><\/jats:sec>Results<\/jats:title>In HC<\/jats:styled-content>, plasma calcium did not significantly change after cinacalcet intake, whereas calcaemia rose up to 3\u00b747\u00a0\u00b1\u00a00\u00b705\u00a0mmol\/l (mean\u00a0\u00b1\u00a0SEM<\/jats:styled-content>) at the end of the calcium load. PTH<\/jats:styled-content> dropped from basal level to a similar extend (\u226580%) with 60\u00a0mg cinacalcet and calcium load, whereas the decrease was significantly lesser (P<\/jats:italic>\u00a0<\u00a00\u00b701) with 30\u00a0mg cinacalcet. In PHPT<\/jats:styled-content>, serum PTH<\/jats:styled-content> levels dropped by 44\u00b78\u00a0\u00b1\u00a06\u00b79% and 58\u00b72\u00a0\u00b1\u00a05\u00b73% 1\u00a0h after the respective intake of 30 and 60\u00a0mg cinacalcet. One hour after the oral intake of 60\u00a0mg cinacalcet, serum PTH<\/jats:styled-content> levels were <8\u00a0ng\/l in HC<\/jats:styled-content> and \u22658\u00a0ng\/l in PHPT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Sixty milligrams of cinacalcet provides similar results as the standardized calcium load test; PHPT<\/jats:styled-content> patients have a lower response to 60\u00a0mg cinacalcet than HC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12729","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T08:03:09Z","timestamp":1422691389000},"page":"663-669","source":"Crossref","is-referenced-by-count":6,"title":["A step towards cinacalcet testing for the diagnosis of primary hyperparathyroidism: comparison with the standardized intravenous calcium loading. A pilot study"],"prefix":"10.1111","volume":"82","author":[{"given":"A.","family":"Cailleux","sequence":"first","affiliation":[{"name":"Department of Endocrinology University Hospital of Rouen Rouen France"},{"name":"Clinical Research Centre INSERM 0204 University Hospital of Rouen Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vuillermet","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital of Rouen Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.","family":"Basuyau","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biology Henri Becquerel Centre Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.","family":"M\u00e9nard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University Hospital of Rouen Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital of Rouen Rouen France"},{"name":"Clinical Research Centre INSERM 0204 University Hospital of Rouen Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital of Rouen Rouen France"},{"name":"Clinical Research Centre INSERM 0204 University Hospital of Rouen Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pr\u00e9vost","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital of Rouen Rouen France"},{"name":"Clinical Research Centre INSERM 0204 University Hospital of Rouen Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp032200"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90328-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90193-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0028"},{"key":"e_1_2_7_7_1","first-page":"N68","article-title":"Clinical presentation of primary hyperparathyroidism in Europe\u2010nationwide cohort analysis on mortality from nonmalignant causes","volume":"17","author":"Nilsson I.L.","year":"2002","journal-title":"Journal of Bone and Mineral 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