{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:18:31Z","timestamp":1781795911093,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There are no consistent data on the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) as defined by normal adjusted calcium and low PTH level. Our aim was to determine the prevalence and the metabolic bone profile of NHYPO in older women, assessing its evolution over time. The second objective was to evaluate the prevalence of other calcium metabolic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The Osteoporosis and Ultrasound Study (OPUS) is a 6\u2010yr prospective study of fracture\u2010related factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 2419 older women (age 55\u201379\u00a0yrs) and 258 younger women (age 30\u201340\u00a0yrs) participated. Complete follow\u2010up data were available in 1416 subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>After calculating the adjusted calcium according to James\u2019 formula, we identified \u2018abnormal\u2019 calcium and PTH using Mahalanobis distances and allocated older women into different pathological categories using reference intervals from the healthy young women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 57 subjects with NHYPO (2\u00b74%). These women had lower than expected bone turnover as assessed by bone alkaline phosphatase (\u221214\u00b75%, 95% CI: \u221226\u00b72 to \u22123\u00b70, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7007), CTX (\u221266\u00b73%, 95% CI: \u221274\u00b70 to \u221256\u00b74, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and osteocalcin (\u221236\u00b78%, 95% CI: \u221245\u00b76 to \u221226\u00b76, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). After 6\u00a0years, of the 35 NHYPO subjects with follow\u2010up data, none developed overt hypoparathyroidism and only 15 (0\u00b76%) subjects had persistent evidence of NHYPO. We also identified 86 subjects (3\u00b76%) affected by hyperparathyroid hypercalcaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first large population\u2010based study to investigate NHYPO in older women. NHYPO is fairly common, not always persistent and is characterized by low bone turnover.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12732","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T07:15:56Z","timestamp":1422861356000},"page":"816-823","source":"Crossref","is-referenced-by-count":19,"title":["Normocalcaemic hypoparathyroidism: prevalence and effect on bone status in older women. The <scp>OPUS<\/scp> study"],"prefix":"10.1111","volume":"82","author":[{"given":"Andrea","family":"Palermo","sequence":"first","affiliation":[{"name":"Academic Unit of Bone Metabolism University of Sheffield Sheffield UK"},{"name":"Department of Endocrinology and Diabetes University Campus Bio\u2010Medico Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Jacques","sequence":"additional","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Gossiel","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry University of Aberdeen Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Roux","sequence":"additional","affiliation":[{"name":"Cochin Hospital Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Felsenberg","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Muskel\u2010 &amp; Knochenforschung Charit\u00e9, Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus\u2010C","family":"Glueer","sequence":"additional","affiliation":[{"name":"Sektion Biomedizinische Bildgebung Klinik f\u00fcr Radiologie und Neuroradiologie Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Eastell","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.2.371"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds105"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001035"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1300"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1414"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1763"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.06.052"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2000"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-4-199902160-00008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411701"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2012.12.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.04.010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.040304"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/23.3.559"},{"key":"e_1_2_7_16_1","first-page":"8","article-title":"Derivation and internal validation of an equation for albumin\u2010adjusted calcium","volume":"27","author":"James M.T.","year":"2008","journal-title":"BMC Clinical Pathology"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.077180"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005815"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/clinchem\/47.8.1410","article-title":"Clinical evaluation of the Elecsys b\u2010CrossLaps serum assay, a new assay for degradation products of type I collagen C\u2010telopeptides","volume":"47","author":"Okabe K.N.","year":"2001","journal-title":"Clinical Chemistry"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0566"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9618-y"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080803"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.470"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32832c4df0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1908"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.06.037"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2802"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90357-3"},{"key":"e_1_2_7_29_1","unstructured":"Misra B.M. 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