{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:35:24Z","timestamp":1791225324691,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Korean Health Technology R&D Project, Ministry of Health, Welfare and Family Affairs, Republic of Korea","award":["A092077"],"award-info":[{"award-number":["A092077"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The association of low vitamin D status with mild cognitive impairment (\n                      <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                      ), a preclinical condition that can lead to dementia, has not yet been fully explored. Our aim was to investigate the association between vitamin D status and the future risk of\n                      <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                      and dementia in older adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting and participants<\/jats:title>\n                    <jats:p>We conducted a population\u2010based prospective study as a part of the Korean Longitudinal Study on Health and Aging. Four hundred and twelve elderly participants who completed evaluations of cognitive function and metabolic parameters in 2005\u20132006 and 2010\u20132011 were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Major outcome measure<\/jats:title>\n                    <jats:p>\n                      The rate of development of\n                      <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                      or dementia during the study period was compared according to baseline vitamin D status. Binary logistic regression analysis was performed to investigate any independent association between vitamin D status and the risks of\n                      <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                      or dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 405 subjects that remained after excluding seven demented subjects at baseline, 338 subjects remained unchanged or improved in their diagnosis for cognitive function during the study period, whereas 67 subjects showed progression to\n                      <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                      or dementia. When analyzing 236 subjects whose baseline mini\u2010mental state examination (\n                      <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>\n                      ) scores were &lt;27, severe vitamin D deficiency at baseline, defined as &lt;25\u00a0nmol\/l, was independently associated with the progression of cognitive impairment. Among 297 subjects who were normal at baseline, 50 acquired\n                      <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                      and 247 remained normal. Severe vitamin D deficiency was also independently associated with the development of\n                      <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                      when analyzing 145 subjects whose baseline\n                      <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>\n                      scores were &lt;27.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Severe vitamin D deficiency was independently associated with the future risk of\n                      <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n                      as well as dementia, especially in older adults whose baseline\n                      <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>\n                      scores had decreased only modestly.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.12733","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T02:14:52Z","timestamp":1422843292000},"page":"36-42","source":"Crossref","is-referenced-by-count":50,"title":["Serum 25\u2010hydroxyvitamin D level and the risk of mild cognitive impairment and dementia: the Korean Longitudinal Study on Health and Aging (\n                    <scp>KL<\/scp>\n                    o\n                    <scp>SHA<\/scp>\n                    )"],"prefix":"10.1111","volume":"83","author":[{"given":"J.H.","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital and Seoul National University College of Medicine Seongnam\u2010si Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital and Seoul National University College of Medicine Seongnam\u2010si Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.W.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Seoul National University Bundang Hospital and Seoul National University College of Medicine Seongnam\u2010si Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital and Seoul National University College of Medicine Seongnam\u2010si Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital and Seoul National University College of Medicine 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