{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:21:22Z","timestamp":1778088082224,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["D121100004912003"],"award-info":[{"award-number":["D121100004912003"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical Research Grants of Chinese PLA General Hospital","award":["13KMM26"],"award-info":[{"award-number":["13KMM26"]}]},{"name":"Ministry of Science and Technology of China","award":["2009BAI86B01"],"award-info":[{"award-number":["2009BAI86B01"]}]},{"name":"Research Foundation by the Ministry of Health of PLA China","award":["13CXZ029"],"award-info":[{"award-number":["13CXZ029"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81072355,81373080"],"award-info":[{"award-number":["81072355,81373080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine associations between metabolic syndrome (MetS) and its individual components with risk of mild cognitive impairment (<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>) among community elderly and explore the age difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>About 2\u00a0102 aged 60 and older community residents in Beijing metropolitan area, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Cognitive function was assessed by Mini\u2010Mental State Examination (<jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>). MetS was defined by the 2009 harmonizing definition. Overnight\u2010fasting blood samples were obtained to measure biochemistry indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of MetS and <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> was 59\u00b71% and 15\u00b79%, respectively. After adjusting age, gender, other demographic factors, lifestyle variables and medication use, participants with MetS or its individual components are at significantly elevated risk for <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>. In terms of <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content> score, as the continuous dependent variable, the \u03b2 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of MetS was \u22120\u00b768(\u22120\u00b799, \u22120\u00b737). For prevalence of <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>, as the dichotomy dependent variable, the odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) of Mets is 1\u00b752 compared to control group (or baseline) with 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of 1\u00b716 to 1\u00b795. The multivariate association only showed significant results among participants aged less than 80\u00a0years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MetS is associated with worse cognitive function among younger elderly. Managing MetS, as well as its components, may contribute to control cognitive decline and reduce related disease and social burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12734","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T07:14:58Z","timestamp":1422861298000},"page":"844-853","source":"Crossref","is-referenced-by-count":47,"title":["Association between metabolic syndrome and mild cognitive impairment and its age difference in a chinese community elderly population"],"prefix":"10.1111","volume":"82","author":[{"given":"Miao","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Geriatrics and Beijing Key Laboratory of Aging and Geriatrics Chinese PLA General Hospital Beijing 100853 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics and Beijing Key Laboratory of Aging and Geriatrics Chinese PLA General Hospital Beijing 100853 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Chinese Traditional Medicine and Acupuncture Chinese PLA General Hospital Beijing 100853 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics and Beijing Key Laboratory of Aging and Geriatrics Chinese PLA General Hospital Beijing 100853 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics and Beijing Key Laboratory of Aging and Geriatrics Chinese PLA General Hospital Beijing 100853 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics and Beijing Key Laboratory of Aging and Geriatrics Chinese PLA General Hospital Beijing 100853 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics and Beijing Key Laboratory of Aging and Geriatrics Chinese PLA General Hospital Beijing 100853 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.032"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.02.031"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3233\/JAD-140389","article-title":"Impact of metabolic syndrome on cognitive decline in older age: Protective or harmful, where is the pitfall?","volume":"41","author":"Frisardi V.","year":"2014","journal-title":"Journal of Alzheimer's Disease"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318065bfd6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.02731.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20037"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01063"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0215"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e31816b7841"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000271381.30143.75"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-121168","article-title":"Metabolic syndrome and cognitive decline in early alzheimer's disease and healthy older adults","volume":"35","author":"Watts A.S.","year":"2013","journal-title":"Journal of Alzheimer's Disease"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1144"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60221-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066233"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_8_18_1","first-page":"187","article-title":"Discussion on application of mmse for senile dementia patients","volume":"4","author":"Peng D.","year":"2005","journal-title":"Chinese Journal of Neuroimmunology and Neurology"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3233\/JAD-121885","article-title":"Metabolic syndrome and amnestic mild cognitive impairment: Singapore longitudinal ageing study\u20102 findings","volume":"34","author":"Feng L.","year":"2013","journal-title":"Journal of Alzheimer's Disease"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332208"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.18.2237"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-091669"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52466.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.12.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.252759"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.04.007"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2005-7107"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2012.10.001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008.08.006"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12734","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:04:09Z","timestamp":1695575049000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,24]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/cen.12734"],"URL":"https:\/\/doi.org\/10.1111\/cen.12734","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,24]]}}}