{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:30:12Z","timestamp":1790803812630,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1021326"],"award-info":[{"award-number":["1021326"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Lower circulating androgens and poorer lung function are associated with increased cardiovascular risk and mortality in men. The association between androgens and lung function is unclear. We tested the hypothesis that circulating testosterone (T) and its metabolites dihydrotestosterone (<jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content>) and oestradiol (E2) are differentially associated with lung function in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Early\u2010morning serum T, <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> and E2 were assayed using mass spectrometry in 1768 community\u2010dwelling men from Busselton, Western Australia. Forced expiratory volume in 1\u00a0s (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1) and forced vital capacity (<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content>) were measured using spirometry. Linear regression models adjusting for age, height, smoking, exercise, body mass index, respiratory conditions and cardiovascular risk factors were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 50.1\u00a0\u00b1\u00a016\u00b78\u00a0years. 16\u00b70% were current smokers, 14\u00b71% reported a history of asthma and 2\u00b77% reported chronic obstructive pulmonary disease. Current smokers had higher T compared with never smokers (age\u2010adjusted mean 14\u00b75 <jats:italic>vs<\/jats:italic> 13\u00b75\u00a0nmol\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7002) and higher E2 (65\u00b73 <jats:italic>vs<\/jats:italic> 60\u00b71 pmol\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7017). In fully adjusted analyses, T was associated with <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1 (51\u00a0ml per 1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> increase, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) as was <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> (62\u00a0ml, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), E2 was not (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7926). Similar results were seen for <jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content> (T: 76\u00a0ml, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001; <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content>: 65\u00a0ml, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001; E2 <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7664). Higher <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> was marginally associated with the ratio <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content> (0\u00b73% per 1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> increase, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both T and <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> were independently associated with higher <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content> in predominantly middle\u2010aged community\u2010dwelling men. Androgens may contribute to, or be biomarkers for, better lung function in men. Further research is needed to clarify whether androgens preserve lung function in ageing men.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12738","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T14:43:14Z","timestamp":1423320194000},"page":"268-276","source":"Crossref","is-referenced-by-count":58,"title":["Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community\u2010dwelling men"],"prefix":"10.1111","volume":"83","author":[{"given":"Shalini S.","family":"Mohan","sequence":"first","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia Perth WA Australia"},{"name":"Department of Endocrinology and Diabetes Fremantle and Fiona Stanley Hospitals Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Knuiman","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Divitini","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan L.","family":"James","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia Perth WA Australia"},{"name":"Department of Pulmonary Physiology and Sleep Medicine Sir Charles Gairdner Hospital Nedlands WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Musk","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia Perth WA Australia"},{"name":"School of Population Health University of Western Australia Perth WA Australia"},{"name":"Department of Respiratory Medicine Sir 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