{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:44:24Z","timestamp":1787496264803,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n Demonstration of unilateral aldosterone production by adrenal venous sampling (\n AVS<\/jats:styled-content>\n ) is required to select appropriate candidates for adrenalectomy in patients with primary aldosteronism (\n PA<\/jats:styled-content>\n ). During\n AVS<\/jats:styled-content>\n , aldosterone and cortisol levels are measured to assess successful cannulation and lateralization. In patients with aldosterone\u2010producing adenoma (\n APA<\/jats:styled-content>\n ), concurrent autonomous cortisol secretion might confound\n AVS<\/jats:styled-content>\n results.\n <\/jats:p>\n <\/jats:sec>\n \n Design and patients<\/jats:title>\n \n We retrospectively examined results in eight patients with cortisol\u2010producing adenoma (\n CPA<\/jats:styled-content>\n ), but without\n PA<\/jats:styled-content>\n , who underwent\n AVS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In all eight, cortisol was higher on the\n CPA<\/jats:styled-content>\n side than\u00a0contralateral (\n CL<\/jats:styled-content>\n ) (median 6\u00b77\u2010fold [range 2\u00b74\u201327\u00b72];\n P<\/jats:italic>\n \u00a0=\u00a00\u00b7012]). By cortisol criteria,\n CL<\/jats:styled-content>\n catheter placement would have been labelled inadequate in six despite adrenal venous aldosterone levels markedly higher than peripheral (41\u00b76\u2010fold [7\u00b72\u2013510\u00b75];\n P<\/jats:italic>\n \u00a0<\u00a00\u00b7001), suggesting successful cannulation. In all eight, adrenal venous aldosterone\/cortisol (A\/C) ratios on the\n CL<\/jats:styled-content>\n side were indicative of increased aldosterone production (\u22652 times peripheral), but in only three patients on the\n CPA<\/jats:styled-content>\n side (difference\n CL<\/jats:styled-content>\n side 44\u00b75\u2010fold [6\u00b70\u2013109\u00b70]\n vs<\/jats:italic>\n CPA<\/jats:styled-content>\n side 1\u00b765\u2010fold [1\u00b70\u201323\u00b70];\n P<\/jats:italic>\n \u00a0=\u00a00\u00b7017). A\/C ratios were higher on the\n CL<\/jats:styled-content>\n vs<\/jats:italic>\n the\n CPA<\/jats:styled-content>\n side in seven (20\u00b70\u2010fold [4\u00b77\u201376\u00b70]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These results in patients with\n CPA<\/jats:styled-content>\n suggest that in patients with\n APA<\/jats:styled-content>\n , concurrent autonomous unilateral cortisol hypersecretion could confound\n AVS<\/jats:styled-content>\n accuracy by increasing cortisol levels (reducing A\/C ratio) on the\n CPA<\/jats:styled-content>\n side, while reducing levels (increasing A\/C ratio and suggesting failed cannulation) on the\n CL<\/jats:styled-content>\n side. Misclassification of\n PA<\/jats:styled-content>\n subtype or repeat\n AVS<\/jats:styled-content>\n could result, underscoring the importance of adequately assessing cortisol production prior to\n AVS<\/jats:styled-content>\n and the need to consider alternatives.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.12750","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T02:02:49Z","timestamp":1423879369000},"page":"456-461","source":"Crossref","is-referenced-by-count":42,"title":["Does concomitant autonomous adrenal cortisol overproduction have the potential to confound the interpretation of adrenal venous sampling in primary aldosteronism?"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-3735","authenticated-orcid":false,"given":"R\u00e9mi","family":"Goupil","sequence":"first","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"},{"name":"H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al University of Montr\u00e9al Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wolley","sequence":"additional","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf H.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stowasser","sequence":"additional","affiliation":[{"name":"Endocrine Hypertension Research Centre University of Queensland School of Medicine Greenslopes and Princess Alexandra Hospitals Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-690X(03)00050-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-5-200909010-00007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"e_1_2_7_5_1","unstructured":"Goupil R. Wolley M. Ungerer J. et\u00a0al.Concomitant autonomous cortisol secretion by aldosterone\u2010producing adenoma: The utility of plasma metadrenaline to assess lateralization during adrenal venous sampling. State of the Heart 2014 \u2010 High Blood Pressure Research Council of Australia annual meeting abstract 2014."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1070"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0125"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2830"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.146613"},{"key":"e_1_2_7_10_1","first-page":"39","article-title":"Laboratory investigation of primary aldosteronism","volume":"31","author":"Stowasser M.","year":"2010","journal-title":"Clin Biochem Rev"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295460"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9332-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02097"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.06.051"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-402"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01022.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.663"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0840"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9793-x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-690"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2253"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2172"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.10.3009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0880533"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01601"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.182469"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12750","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T05:35:28Z","timestamp":1695533728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,17]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/cen.12750"],"URL":"https:\/\/doi.org\/10.1111\/cen.12750","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,17]]}}}