{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:57:17Z","timestamp":1764997037549},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Many lines of evidence indicate that dehydroepiandrosterone (DHEA) plays a distinct role in bone metabolism and that its sulphated form (DHEA\u2010S), which is easily measured in blood, may be a potential biomarker of osteoporosis\u2010related phenotypes. However, most previous epidemiologic studies focused on postmenopausal women and reported conflicting results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to investigate the association between the serum DHEA\u2010S level and bone mass in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>This large cross\u2010sectional study included 1089 healthy Korean men who participated in a routine health screening examination. Bone mineral density (BMD) at the lumbar spine, total femur, femur neck, and trochanter and serum DHEA\u2010S level were obtained in all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustment for age, body mass index, lifestyle factors and serum levels of calcium, phosphorus, testosterone, 25\u2010OH\u2010vitamin D3 and cortisol, higher serum DHEA\u2010S concentrations were associated with higher BMD values at all skeletal sites. Consistently, compared to the subjects in the highest DHEA\u2010S quartile (Q4), those in the lowest DHEA\u2010S quartile (Q1) showed significantly lower BMD values. Multiple logistic regression analyses revealed that the odds ratios for the risk of lower BMD (T\u2010score &lt;\u22121) increased in a dose\u2010dependent manner across decreasing DHEA\u2010S quartiles and the odds for the risk of lower BMD were 2\u00b759\u2010fold higher in Q1 than in Q4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings support previous evidences that DHEA\u2010S has favourable effects on bone mass in men and suggest that a low serum DHEA\u2010S level may be a potential risk factor for male osteoporosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12755","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T10:58:56Z","timestamp":1424257136000},"page":"173-179","source":"Crossref","is-referenced-by-count":13,"title":["The association between serum dehydroepiandrosterone Sulphate (DHEA\u2010S) level and bone mineral density in Korean men"],"prefix":"10.1111","volume":"83","author":[{"given":"Dain","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeonmok","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Hee","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Asan Medical Center University of Ulsan College of Medicine Seoul 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