{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:31:04Z","timestamp":1782603064613,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Hospital Organization"},{"name":"Ministry of Health, Labor and Welfare, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Summary<\/jats:title>Objectives<\/jats:title>Adrenal vein sampling (AVS<\/jats:styled-content>) is the standard criterion for the subtype diagnosis in primary aldosteronism (PA<\/jats:styled-content>). Although lateralized index (LI<\/jats:styled-content>) \u22654 after cosyntropin stimulation is the commonly recommended cut\u2010off for unilateral aldosterone hypersecretion, many of the referral centres in the world use LI<\/jats:styled-content> cut\u2010off of <4 without sufficient evidence for its diagnostic accuracy.<\/jats:p><\/jats:sec>Aim<\/jats:title>The aim of the study was to establish the diagnostic significance of contralateral (CL<\/jats:styled-content>) aldosterone suppression for the subtype diagnosis in patients with LI<\/jats:styled-content> <4 in AVS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Design and patients<\/jats:title>A retrospective multicentre study was conducted in J<\/jats:styled-content>apan. Of 124 PA<\/jats:styled-content> patients subjected to unilateral adrenalectomy after successful AVS<\/jats:styled-content> with cosyntropin administration, 29 patients with LI<\/jats:styled-content>\u00a0<\u00a04 were included in the study. The patients were divided into G<\/jats:styled-content>roup A<\/jats:styled-content> with CL<\/jats:styled-content> suppression (n<\/jats:italic>\u00a0=\u00a016) and G<\/jats:styled-content>roup B<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a013) without CL<\/jats:styled-content> suppression. Three outcome indices were assessed after 6\u00a0months postoperatively: normalization\/significant improvement of hypertension, normalization of the aldosterone to renin ratio (ARR<\/jats:styled-content>) and normalization of hypokalaemia.<\/jats:p><\/jats:sec>Results<\/jats:title>The normalization\/significant improvement of hypertension was 81% in G<\/jats:styled-content>roup A<\/jats:styled-content> and 54% in G<\/jats:styled-content>roup B<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b72). The normalization of ARR<\/jats:styled-content> was 100% in G<\/jats:styled-content>roup A<\/jats:styled-content> and 46% in G<\/jats:styled-content>roup B<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7004). Hypokalaemia was normalized in all patients of both groups. The overall cure rate of PA<\/jats:styled-content> based on meeting all the three criteria was 81% in G<\/jats:styled-content>roup A<\/jats:styled-content> and 31% in G<\/jats:styled-content>roup B<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b701).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In patients with PA<\/jats:styled-content>, where the LI<\/jats:styled-content> is <4 on AVS<\/jats:styled-content>, CL<\/jats:styled-content> suppression of aldosterone is an accurate predictor of a unilateral source of aldosterone excess. CL<\/jats:styled-content> suppression data should be interpreted in conjunction with computed tomographic adrenal imaging findings to guide surgical management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12761","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T08:32:27Z","timestamp":1425285147000},"page":"462-467","source":"Crossref","is-referenced-by-count":51,"title":["Importance of contralateral aldosterone suppression during adrenal vein sampling in the subtype evaluation of primary aldosteronism"],"prefix":"10.1111","volume":"83","author":[{"given":"Hironobu","family":"Umakoshi","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Hypertension National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Tanase\u2010Nakao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Hypertension National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Sapporo City Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Ichijo","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Saiseikai Yokohama City Toubu Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Sone","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuya","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuyuki","family":"Katabami","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Yokohama City Seibu Hospital St. Marianna University School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Kamemura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Akashi Medical Center Akashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sanda City Hospital Sanda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima General Hospital of West Japan Railway Company Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Kai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Tondabayashi Hospital Tondabayashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomikazu","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Matsuyama Red Cross Hospital Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ogo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Public Health Kitasato University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Tsuiki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Hypertension National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shimatsu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Hypertension National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhide","family":"Naruse","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Hypertension National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031337"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4146"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-5-200909010-00007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2830"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02097"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70069-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.3.1066"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-022051"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2345"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ11-0133"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.20"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.06.051"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1252060"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.184.3.1509049"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.111369"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2803"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299681"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.134759"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2788"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328362add3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1221-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318165c075"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2001.022"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1210\/jcem.86.3.7287","article-title":"Identification of the etiology of primary aldosteronism with adrenal vein sampling in patients with equivocal computed tomography and magnetic resonance findings: results in 104 consecutive cases","volume":"86","author":"Rossi G.P.","year":"2001","journal-title":"The Journal of Clinical Endocrinology and Metabolism"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12761","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:35:18Z","timestamp":1695548118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,16]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/cen.12761"],"URL":"https:\/\/doi.org\/10.1111\/cen.12761","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,16]]}}}