{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:35:56Z","timestamp":1764873356416,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NovoNordisk"},{"name":"Above and Beyond Charitable Trustees"},{"name":"Merck Serono"},{"DOI":"10.13039\/501100014382","name":"Ipsen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014382","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Bone marrow transplantation with total body irradiation (BMT<\/jats:styled-content>\/TBI<\/jats:styled-content>) has adverse effects on growth, growth hormone status and adiposity. We investigated the GH<\/jats:styled-content>\u2013IGF<\/jats:styled-content>\u2010I<\/jats:styled-content> axis in relation to adiposity.<\/jats:p><\/jats:sec>Design<\/jats:title>Cross\u2010sectional case control study.<\/jats:p><\/jats:sec>Patients<\/jats:title>BMT<\/jats:styled-content>\/TBI<\/jats:styled-content> survivors (n<\/jats:italic>\u00a0=\u00a022) and short stature control participants (n<\/jats:italic>\u00a0=\u00a019), all GH<\/jats:styled-content>\u2010na\u00efve or off GH<\/jats:styled-content> treatment >3\u00a0months.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Auxology, DEXA<\/jats:styled-content> scans and GH<\/jats:styled-content>\u2013IGF<\/jats:styled-content>\u2010I<\/jats:styled-content> axis investigation: (i) 12\u2010h overnight GH<\/jats:styled-content> profiles; (ii) insulin tolerance test (ITT<\/jats:styled-content>); and (iii) IGF<\/jats:styled-content>\u2010I<\/jats:styled-content> generation test. Analysis: auto\u2010deconvolution of GH<\/jats:styled-content> profile data and comparison of quantitative parameters using anova<\/jats:sc>.<\/jats:p><\/jats:sec>Results<\/jats:title>Eighty\u2010two percent of BMT<\/jats:styled-content>\/TBI<\/jats:styled-content> survivors had growth hormone deficiency (GHD<\/jats:styled-content>) using ITT<\/jats:styled-content>. GH<\/jats:styled-content> profile area\u2010under\u2010the\u2010curve (GH<\/jats:styled-content>\u2010AUC<\/jats:styled-content>) was reduced in BMT<\/jats:styled-content>\/TBI<\/jats:styled-content> survivors vs<\/jats:italic> short stature control participants [geometric mean (range) 209 (21\u2013825) vs<\/jats:italic> 428 (64\u20131400) mcg\/l\/12\u00a0h, respectively, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7007]. GHD<\/jats:styled-content> was more marked in those who had additional cranial irradiation (CRT<\/jats:styled-content>) [ITT<\/jats:styled-content> peak 1\u00b74 (0\u00b72\u20133\u00b70) vs <\/jats:italic>TBI<\/jats:styled-content> only 4\u00b71 (1\u00b71\u201314\u00b78) mcg\/l, P<\/jats:italic>\u00a0=\u00a00\u00b7036]. GHD<\/jats:styled-content> was more marked at the end of growth in BMT<\/jats:styled-content>\/TBI<\/jats:styled-content> survivors vs<\/jats:italic> short stature control participants (GH<\/jats:styled-content>\u2010AUC<\/jats:styled-content> 551 (64\u20132474) vs<\/jats:italic> 1369 (192\u20134197) mcg\/l\/12\u00a0h, respectively, P<\/jats:italic>\u00a0=\u00a00\u00b7011) and more prevalent (9\/11 vs<\/jats:italic> 1\/9, respectively, P<\/jats:italic>\u00a0=\u00a00\u00b7005). GH<\/jats:styled-content> profile data were consistent with ITT<\/jats:styled-content> results in 80% of participants. IGF<\/jats:styled-content>\u2010I<\/jats:styled-content> generation tests were normal. BMT<\/jats:styled-content>\/TBI<\/jats:styled-content> survivors still demonstrated lower GH<\/jats:styled-content> levels after adjustment for adiposity (fat\u2010adjusted mean difference for GH<\/jats:styled-content>\u2010AUC<\/jats:styled-content> 90\u00b79\u00a0mcg\/l\/12\u00a0h, P<\/jats:italic>\u00a0=\u00a00\u00b7025).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>GHD<\/jats:styled-content> was more prevalent in BMT<\/jats:styled-content>\/TBI<\/jats:styled-content> survivors than expected for the CRT<\/jats:styled-content> dose in TBI<\/jats:styled-content>, worsened with time and persisted into adulthood. GHD<\/jats:styled-content> could not be explained by adiposity. There was no evidence of GH<\/jats:styled-content> neurosecretory dysfunction or resistance after BMT<\/jats:styled-content>\/TBI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12773","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T15:47:47Z","timestamp":1427212067000},"page":"508-517","source":"Crossref","is-referenced-by-count":14,"title":["Growth hormone deficiency after childhood bone marrow transplantation with total body irradiation: interaction with adiposity and age"],"prefix":"10.1111","volume":"83","author":[{"given":"N.L.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetes University Hospitals Bristol NHS Foundation Trust Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.E.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Stem Cells Ageing and Molecular Physiology Unit Research Institute for Sport & Exercise Sciences Liverpool John Moores University Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Moss","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science Manchester Metropolitan University Crewe Cheshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.W.W.","family":"Woltersdorf","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetes University Hospitals Bristol NHS Foundation Trust Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.P.","family":"Hunt","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences University of Bristol Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.","family":"Elson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetes University Hospitals Bristol NHS Foundation Trust Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Cornish","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology University Hospitals Bristol NHS Foundation Trust Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.G.","family":"Stevens","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences University of Bristol Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.C.","family":"Crowne","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetes University Hospitals Bristol NHS Foundation Trust Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704324"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000207607"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.3.597"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067834"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050006"},{"key":"e_1_2_8_7_1","first-page":"4109","article-title":"Final height of patients who underwent bone marrow transplantation for hematological disorders during childhood: a study by the Working Party for Late Effects\u2010EBMT","volume":"93","author":"Cohen A.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1360331"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1525"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1500329"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.2.819.bloodjournal862819"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064768"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1570225"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.6.472"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2007.04.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.7.2460"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-2-428"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800807"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0128"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2599"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.6.689"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2004.08.006"},{"key":"e_1_2_8_23_1","first-page":"163","article-title":"Growth, growth hormone and final height after BMT. 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