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We therefore aimed to evaluate the relationships between fasting <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 levels, body fat mass and other obesity markers in a large sample of young and healthy adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Patients<\/jats:title><jats:p>Our population\u2010based study included 2096 individuals aged 24\u201344. Exclusion criteria were prevalent cardiovascular disease, diabetes or a body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) &gt;35\u00a0kg\/m<jats:sup>2<\/jats:sup>. Body fat mass was obtained by bioelectrical impedance analysis. Multivariable linear regression models were constructed to assess the relationships of <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 with various measures of body composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age of our population was 37\u00a0years, median <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 24\u00b71\u00a0kg\/m<jats:sup>2<\/jats:sup> and median body fat 25\u00b71%. A strong positive correlation was observed in age\u2010adjusted models between <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 and fat mass in men (\u03b2 (95% confidence interval) 1\u00b738 (0\u00b769; 2\u00b707), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and women (1\u00b727 (0\u00b765; 1\u00b789), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) as well as fully adjusted models including <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in men [0\u00b787 (0\u00b727; 1\u00b746), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701] but not women [0\u00b729 (\u22120\u00b707; 0\u00b764), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b711]. The relationships of <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> for men and women [0\u00b700 (\u22120\u00b734; 0\u00b734), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b799] [\u22120\u00b702 (\u22120\u00b728; 0\u00b725), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b791] and waist circumference [0\u00b743 (\u22120\u00b745; 1\u00b730), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b734] [0\u00b737 (\u22120\u00b744; 1\u00b718), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b737], respectively, were not significant after multivariable adjustment including fat mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among young and healthy adults, <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 levels are strongly and independently related to body fat mass especially in men but not <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> or waist circumference. These results raise the\u00a0hypothesis that <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 may be implicated in body fat mass regulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12789","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T23:08:49Z","timestamp":1428707329000},"page":"636-642","source":"Crossref","is-referenced-by-count":14,"title":["Plasma levels of glucagon\u2010like peptide 1 and markers of obesity among young and healthy adults"],"prefix":"10.1111","volume":"83","author":[{"given":"Jan Gerrit","family":"van der Stouwe","sequence":"first","affiliation":[{"name":"Department of Medicine University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Aeschbacher","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Krisai","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schoen","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Meyre","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Todd","sequence":"additional","affiliation":[{"name":"Singulex, Inc. 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