{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:32:09Z","timestamp":1785828729754,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Society of Pediatric Endocrinology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The role of incretins in type 2 diabetes is controversial. This study investigated the association between incretin levels in obese Korean children and adolescents newly diagnosed with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We performed a 2\u2010hr oral glucose tolerance test (OGTT) in obese children and adolescents with type 2 diabetes and with normal glucose tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Twelve obese children and adolescents with newly diagnosed type 2 diabetes (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> group) and 12 obese age\u2010matched subjects without type 2 diabetes (<jats:styled-content style=\"fixed-case\">NDM<\/jats:styled-content> group) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>An OGTT was conducted and insulin, C\u2010peptide, glucagon, glucagon\u2010like peptide\u20101 (<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101) and glucose\u2010dependent insulinotropic polypeptide (<jats:styled-content style=\"fixed-case\">GIP<\/jats:styled-content>) were measured during the <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 13\u00b78\u00a0\u00b1\u00a02\u00b70\u00a0years, and the mean body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) Z\u2010score was 2\u00b71\u00a0\u00b1\u00a00\u00b75. The groups were comparable in age, sex, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> Z\u2010score and waist:hip ratio. The <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> group had significantly lower homeostasis model assessment of \u03b2 and insulinogenic index values (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). The homeostasis model assessment of insulin resistance index was not different between the two groups. Insulin and C\u2010peptide secretions were significantly lower in the <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> group than in the <jats:styled-content style=\"fixed-case\">NDM<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Total <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 secretion was significantly higher in the <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> group while intact <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">GIP<\/jats:styled-content> secretion values were not significantly different between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Impaired insulin secretion might be important in the pathogenesis of type 2 diabetes in obese Korean children and adolescents, however, which may not be attributed to incretin secretion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12802","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T07:57:09Z","timestamp":1429689429000},"page":"72-79","source":"Crossref","is-referenced-by-count":5,"title":["Incretin secretion in obese Korean children and 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