{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T14:19:01Z","timestamp":1699625941275},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mild or borderline congenital hypothyroidism [often referred to as mild neonatal hyperthyrotropinemia (<jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content>)] is characterized by an abnormal newborn screen (<jats:styled-content style=\"fixed-case\">NBS<\/jats:styled-content>), followed by mildly elevated <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and normal <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 on confirmatory testing. This condition is increasingly observed, but data regarding optimal management are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Examine the use of routine technetium thyroid scanning (<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>) in the management of <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of infants with <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content> between 2000 and 2011. We assessed the clinical course of infants with <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content> according to <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> results; as a comparator, infants with classic congenital hypothyroidism (<jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>) were analysed in parallel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 69 infants (52% boys) with <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content> and 164 (34% boys) with classic <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> results were divided into four subgroups: no uptake in 7% of <jats:styled-content style=\"fixed-case\">MNH <\/jats:styled-content><jats:italic>vs<\/jats:italic> 24% of classic <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701), decreased uptake\/anatomical abnormalities in 39% <jats:italic>vs<\/jats:italic> 46% (p\u00a0=\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>), increased uptake in 35% <jats:italic>vs<\/jats:italic> 26% (p\u00a0=\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>) and normal uptake in 19% <jats:italic>vs<\/jats:italic> 4% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701). In <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content>, neither <jats:styled-content style=\"fixed-case\">NBS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>, confirmatory <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4, mean <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>\u20104 treatment doses and number of dose escalations, nor post\u2010treatment <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> differed among the four subgroups. In contrast, clinical features in infants with classic <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> differed among the subgroups. Among <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content> infants who reached 3\u00a0years of age, trial\u2010off treatment was successful in 6 of 11 (55%) with no apparent difference in success rates among <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The information provided by <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> during evaluation of <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content> does not predict clinical course; obtaining these scans in infants with <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content> may not be an effective use of healthcare resources.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12807","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T15:38:22Z","timestamp":1430235502000},"page":"438-444","source":"Crossref","is-referenced-by-count":3,"title":["Use of Tc\u201099\u00a0m thyroid scans in borderline congenital hypothyroidism"],"prefix":"10.1111","volume":"84","author":[{"given":"Asaf","family":"Oren","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"},{"name":"Department of Pediatrics University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Brnjac","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid H.","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"},{"name":"Department of Pediatrics University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Palmert","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"},{"name":"Department of Pediatrics University of Toronto Toronto ON Canada"},{"name":"Department of Physiology University of Toronto Toronto ON 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