{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:42Z","timestamp":1787014002036,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Survival following treatment of paediatric medulloblastomas has significantly improved over the past few decades, but as a consequence, late effects, particularly endocrine sequelae, have been recognized. The complete picture of late effects, however, has been limited by short duration of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To establish the evolution of endocrine sequelae in patients treated for medulloblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010centre analysis of medulloblastoma treatment and endocrine sequelae in patients diagnosed between 1982 and 2002.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 109 patients were treated for medulloblastoma, with various treatment modalities involving radio\u2010 and chemotherapy. Only 45 (41%) patients remained alive, and details of treatment and late effects were available for 35 (25\u00a0\n                      <jats:sc>m<\/jats:sc>\n                      ). The median age at diagnosis was 8 (range 2\u201314) years, and the median follow\u2010up was 18 (range 10\u201328) years. Growth hormone deficiency (\n                      <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content>\n                      ) was the most prevalent hormone deficiency (97%), followed by primary hypothyroidism (60%) and adrenocorticotrophic hormone (\n                      <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\n                      ) deficiency (45\u00b75%). The median time from end of treatment to loss of growth hormone was 1\u00b77 (range 0\u00b77\u201315) years,\n                      <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\n                      deficiency 2\u00b79 (range 0\u00b775\u20137\u00b75) years and hypothyroidism 4\u00b71 (range 0\u00b77\u201311\u00b74) years. Twenty\u2010three percentage developed hypogonadism (17% primary and 6% secondary), whilst precocious puberty was seen in 20%. Endocrinopathies appeared to be more prevalent in those treated with concomitant chemotherapy and radiotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prevalence of endocrine sequelae in medulloblastoma survivors is high, and evolution of endocrine dysfunction can occur as late as 15\u00a0years from treatment completion; hence, long\u2010term close monitoring of growth, puberty and gonadal function is essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.12815","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T02:35:05Z","timestamp":1431052505000},"page":"663-670","source":"Crossref","is-referenced-by-count":35,"title":["Endocrine sequelae beyond 10\u00a0years in survivors of medulloblastoma"],"prefix":"10.1111","volume":"83","author":[{"given":"Suma","family":"Uday","sequence":"first","affiliation":[{"name":"Paediatric Endocrinology Leeds Children's Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Murray","sequence":"additional","affiliation":[{"name":"Endocrinology St James's University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Picton","sequence":"additional","affiliation":[{"name":"Paediatric Oncology &amp; 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