{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:46:55Z","timestamp":1790264815397,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Thyrdel study","award":["EMR200007-503"],"award-info":[{"award-number":["EMR200007-503"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Signs and symptoms of thyrotoxicosis are not specific, and thyroid function tests are frequently prescribed to recognize such thyroid dysfunction. Ultrasensitive assays of thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) allow early diagnosis and identification of mild hyperthyroidism (generally designed as \u2018subclinical\u2019). The aim of this study was to re\u2010evaluate the clinical picture of thyrotoxicosis in the context of the current large utilization of ultrasensitive <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective descriptive cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical presentation of 1572 patients with a recent (&lt;3\u00a0months) diagnosis of thyrotoxicosis recruited by a large representative sample of 263 French endocrinologists was studied using two questionnaires (one at inclusion and the second after 3\u00a0months) concerning symptoms, hormonal evaluation and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1240 (78\u00b79%) patients were women, mean age 48\u00a0\u00b1\u00a017\u00a0years. Subclinical hyperthyroidism (<jats:styled-content style=\"fixed-case\">SCHT<\/jats:styled-content>) was present in 86 patients (10\u00b74%). Symptoms of thyrotoxicosis were in decreasing frequency order: palpitations, weakness, heat\u2010related signs and disturbed sleep. A total of 64\u00b79% of patients had lost weight. Signs and symptoms were more frequent in Graves' disease, in young patients, and were partially related to biochemical severity. Symptoms were less frequent in elderly patients except for cardiac manifestations (atrial fibrillation). Most patients with <jats:styled-content style=\"fixed-case\">SCHT<\/jats:styled-content> had one or several signs or symptoms of thyrotoxicosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirms that elderly patients have less symptoms of thyrotoxicosis than younger subjects but are at increased risk of cardiac complications. Our results show that most patients with \u2018subclinical\u2019 <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> have in fact signs or symptoms of thyrotoxicosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12816","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T14:42:49Z","timestamp":1431182569000},"page":"445-451","source":"Crossref","is-referenced-by-count":80,"title":["Clinical presentation of hyperthyroidism in a large representative sample of outpatients in France: relationships with age, aetiology and hormonal parameters"],"prefix":"10.1111","volume":"84","author":[{"given":"B.","family":"Goichot","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Endocrinology and Nutrition H\u00f4pitaux Universitaires de Strasbourg Strasbourg France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ph.","family":"Caron","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Metabolic diseases and Nutrition P\u00f4le Cardio\u2010vasculaire et M\u00e9tabolique CHU Larrey Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Landron","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Merck Serono Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bou\u00e9e","sequence":"additional","affiliation":[{"name":"CEMKA Bourg La Reine France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1977.tb01340.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01894.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14073-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)89462-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.4.526"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0481"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245254"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90547-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380030132023"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.803"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1996.tb05637.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.12968\/hosp.1999.60.2.1808"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2495"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.119370"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311901"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.9.1033"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60276-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.17.3.456"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.04.009"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12816","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:39:29Z","timestamp":1695490769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,4]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/cen.12816"],"URL":"https:\/\/doi.org\/10.1111\/cen.12816","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,4]]}}}