{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:50:57Z","timestamp":1790128257239,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T00:00:00Z","timestamp":1434672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001529","name":"Waikato Medical Research Foundation","doi-asserted-by":"publisher","award":["208"],"award-info":[{"award-number":["208"]}],"id":[{"id":"10.13039\/501100001529","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There are limited data on the incidence of iodinated contrast\u2010induced thyrotoxicosis, particularly in iodine\u2010deficient regions. The aim of this study was to determine the incidence of iodinated contrast\u2010induced thyrotoxicosis and to determine whether thyrotoxicosis was more common in patients \u226570\u00a0years compared to those &lt;70\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective study of adult patients undergoing an outpatient <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> with iodinated contrast was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Thyroid function tests (<jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content>s) and urine iodine measurements were performed prior to the scan. <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content>s were repeated at 4\u2010 and 8\u2010weeks postscan. Changes in <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content>s from baseline were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 102 patients were included in the final analysis. Overall, <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> levels dropped (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70002), and free T<jats:sub>3<\/jats:sub> (<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content><jats:sub>3<\/jats:sub>) levels increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704) between baseline and week 4 with normalization by week 8; however, these changes were not considered clinically significant. No significant differences in free T<jats:sub>4<\/jats:sub> (<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content><jats:sub>4<\/jats:sub>) occurred in the overall group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b782). There were no differences in <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content>s between baseline and 4 or 8\u00a0weeks for those patients aged &lt;70 compared to \u226570\u00a0years. Two patients developed new subnormal <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> values. Of these, one had a 90\u2010mm follicular variant papillary thyroid carcinoma diagnosed while the other had a normal thyroid assessment and <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> spontaneously normalized by 12\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Only 2% of patients developed subclinical hyperthyroidism following a standard dose of iodinated contrast for <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> investigations. Given the low incidence of iodine\u2010induced thyrotoxicosis, there is no indication for routine pre\u2010 and post\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> thyroid function testing in our region.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12818","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T15:18:06Z","timestamp":1431703086000},"page":"558-563","source":"Crossref","is-referenced-by-count":20,"title":["A low incidence of iodine\u2010induced hyperthyroidism following administration of iodinated contrast in an iodine\u2010deficient region"],"prefix":"10.1111","volume":"84","author":[{"given":"Carol","family":"Jarvis","sequence":"first","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Simcox","sequence":"additional","affiliation":[{"name":"Department of Radiology Waikato Hospital Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade A. U.","family":"Tamatea","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"McAnulty","sequence":"additional","affiliation":[{"name":"Department of Radiology Waikato Hospital Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goswin Y.","family":"Meyer\u2010Rochow","sequence":"additional","affiliation":[{"name":"Department of Surgery Waikato Hospital Hamilton New Zealand"},{"name":"Waikato Clinical School Faculty of Medical and Health Science University of Auckland Hamilton New\u00a0Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Conaglen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne S.","family":"Elston","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"},{"name":"Waikato Clinical School Faculty of Medical and Health Science University of Auckland Hamilton New\u00a0Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,19]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization. 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