{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:18:31Z","timestamp":1781795911335,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is limited knowledge about the natural history of normocalcaemic, vitamin D\u2010sufficient hyperparathyroidism (<jats:styled-content style=\"fixed-case\">nHPT<\/jats:styled-content>). The aim was to study the prevalence of <jats:styled-content style=\"fixed-case\">nHPT<\/jats:styled-content> and its relation to morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional and retrospective study at the Sahlgrenska University Hospital, Gothenburg, Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>A random population of 608 men and women, age 25\u201364\u00a0years, was studied in 1995 as part of the <jats:styled-content style=\"fixed-case\">WHO MONICA<\/jats:styled-content> study and reinvestigated in 2008 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0410, of whom 277 were vitamin D sufficient).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>A serum intact parathyroid hormone (S\u2010<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) \u226560\u00a0ng\/l was considered as <jats:styled-content style=\"fixed-case\">HPT<\/jats:styled-content>, S\u2010calcium 2\u00b715\u20132\u00b749\u00a0mmol\/l as normocalcaemia and S\u201025(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D\u00a0\u2265\u00a050\u00a0nmol\/l as vitamin D sufficiency. Data on fractures, stroke and myocardial infarction were retrieved until 2013, that is a 17\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">nHPT<\/jats:styled-content> was 2\u00b70% in 1995 (age 25\u201364) and 11\u00b70% in 2008 (age 38\u201379). S\u2010<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> was positively correlated with age and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. After adjustment for these variables, a high S\u2010<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> level (\u226560\u00a0ng\/l) at follow\u2010up was associated with previously low S\u201025(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D, high osteocalcin, S\u2010<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> and both past and presently treated hypertension. No relation was seen with creatinine, cystatin C, malabsorption markers, thyroid function, glucose, insulin, lipids, calcaneal quantitative ultrasound, fractures, myocardial infarction, stroke or death at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This small random population study showed that <jats:styled-content style=\"fixed-case\">nHPT<\/jats:styled-content> was common, 11% at follow\u2010up. Only one individual developed mild hypercalcaemia in 13\u00a0years. Previous S\u2010<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> was predictive of <jats:styled-content style=\"fixed-case\">nHPT<\/jats:styled-content> and hypertension was prevalent, but no increase in hard end\u2010points was seen over a 17\u2010year period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12819","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T12:05:33Z","timestamp":1431950733000},"page":"277-284","source":"Crossref","is-referenced-by-count":45,"title":["Normocalcaemic, vitamin D\u2010sufficient hyperparathyroidism \u2013 high prevalence and low morbidity in the general population: A long\u2010term follow\u2010up study, the <scp>WHO MONICA<\/scp> project, Gothenburg, Sweden"],"prefix":"10.1111","volume":"83","author":[{"given":"Georgios","family":"Kontogeorgos","sequence":"first","affiliation":[{"name":"Section\u00a0for Endocrinology Department of Medicine Sahlgrenska University Hospital at Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Trimpou","sequence":"additional","affiliation":[{"name":"Section\u00a0for Endocrinology Department of Medicine Sahlgrenska University Hospital at Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Laine","sequence":"additional","affiliation":[{"name":"Section\u00a0for Endocrinology Department of Medicine Sahlgrenska University Hospital at Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Oler\u00f6d","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Sahlgrenska University Hospital at Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Lindahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Sahlgrenska University Hospital at Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Landin\u2010Wilhelmsen","sequence":"additional","affiliation":[{"name":"Section\u00a0for Endocrinology Department of Medicine Sahlgrenska University Hospital at Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/clinchem\/33.8.1364","article-title":"Highly sensitive two\u2010site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia","volume":"33","author":"Nussbaum S.R.","year":"1987","journal-title":"Clinical Chemistry"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2012.12.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1763"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1414"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31823bbb9b"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2802"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302010000200004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0589"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq134"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1621"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.11.024"},{"key":"e_1_2_7_13_1","volume-title":"Dietary Reference Intakes for Calcium and Vitamin D. 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