{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:56:27Z","timestamp":1790200587246,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumour\u2010induced osteomalacia (<jats:styled-content style=\"fixed-case\">TIO<\/jats:styled-content>) is a rare disorder characterized by hypophosphataemic osteomalacia caused by small mesenchymal tumours secreting fibroblast growth factor 23 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content> 23). The most difficult part in the management of these patients is the localization of tumours causing <jats:styled-content style=\"fixed-case\">TIO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We describe the utility of Gallium (Ga)\u201068 <jats:styled-content style=\"fixed-case\">DOTANOC PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> in the localization of tumours causing <jats:styled-content style=\"fixed-case\">TIO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The study was conducted in a single tertiary referral university teaching hospital in India. Ten patients with <jats:styled-content style=\"fixed-case\">TIO<\/jats:styled-content> who underwent Ga\u201068 <jats:styled-content style=\"fixed-case\">DOTANOC PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> from the time period 2009 to 2014 were included in this study. Their detailed clinical history, biochemical parameters, imaging modalities, surgical interventions, histopathology and outcomes were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ga\u201068 <jats:styled-content style=\"fixed-case\">DOTANOC PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> could correctly localize the tumours in <jats:styled-content style=\"fixed-case\">TIO<\/jats:styled-content> in 9 of the 10 cases in which it was performed. Complete resection of the tumour led to full clinical recovery in six of the ten patients; two patients who had partial resection and one patient who underwent radiofrequency ablation showed partial remission. One patient in whom Ga\u201068 <jats:styled-content style=\"fixed-case\">DOTANOC PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was positive in vertebral body with a low standardized uptake value (<jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>) did not show up the tumour on surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that Ga\u201068 <jats:styled-content style=\"fixed-case\">DOTANOC PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> can be used as the first imaging modality in patients diagnosed with <jats:styled-content style=\"fixed-case\">TIO<\/jats:styled-content>. The extremely good outcome following the resection of these small otherwise undiagnosed tumours far outweighs its cost even in resource limited settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12822","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T04:31:04Z","timestamp":1432182664000},"page":"134-140","source":"Crossref","is-referenced-by-count":29,"title":["Utility of Gallium\u201068 <scp>DOTANOC PET<\/scp>\/<scp>CT<\/scp> in the localization of Tumour\u2010induced osteomalacia"],"prefix":"10.1111","volume":"84","author":[{"given":"Nisha","family":"Bhavani","sequence":"first","affiliation":[{"name":"Department of Endocrinology Amrita Institute of Medical Sciences Cochin India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adlyne","family":"Reena Asirvatham","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Amrita Institute of Medical Sciences Cochin India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Kallur","sequence":"additional","affiliation":[{"name":"HCG Anderson Scans Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun S.","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Amrita Institute of Medical Sciences Cochin India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen V.","family":"Pavithran","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Amrita Institute of Medical Sciences Cochin India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasantha","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Amrita Institute of Medical Sciences Cochin India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakumar R.","family":"Vasukutty","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Amrita Institute of Medical Sciences Cochin India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Amrita Institute of Medical Sciences Cochin India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Amrita Institute of Medical Sciences Cochin India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"554","article-title":"Vehlinger E 1959 Rachitis. Infolge, knochen tumors","volume":"14","author":"Prader V.","year":"1959","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ten.0000157816.48111.cb"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21562"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-3919.106702"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000257180.03964.51"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-011-0095-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31818866bf"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182996293"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1642"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.111724"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-0755-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318279eb13"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3642"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/01913129109016242"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200401000-00001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12426"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1881"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000460"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.04.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4515"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12822","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:25:15Z","timestamp":1695479115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,15]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/cen.12822"],"URL":"https:\/\/doi.org\/10.1111\/cen.12822","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,15]]}}}