{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:41:40Z","timestamp":1785840100603,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Pre\u2010operative imaging techniques have enabled minimally invasive parathyroid surgery to supersede the traditional approach to hyperparathyroidism (HPT<\/jats:styled-content>) surgery, which included cervical exploration. Cervical ultrasound (US<\/jats:styled-content>) and sestamibi scan (MIBI<\/jats:styled-content>) are commonly performed, but the results of these localization tests do not always match. This study correlated surgical outcomes with pre\u2010operative localization findings, including matched positive US<\/jats:styled-content> and MIBI<\/jats:styled-content> studies, one positive study (US<\/jats:styled-content> or MIBI<\/jats:styled-content>), conflicting studies or negative results.<\/jats:p><\/jats:sec>Design<\/jats:title>Retrospective medical record review.<\/jats:p><\/jats:sec>Patients<\/jats:title>A hundred and sixty nine consecutive patients who underwent parathyroidectomy from January 2005 to December 2012.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Correlation between surgical outcomes and pre\u2010operative localization tests.<\/jats:p><\/jats:sec>Results<\/jats:title>All patients (134F\/35M, 59\u00b76\u00a0\u00b1\u00a013\u00b75\u00a0years of age) had primary HPT<\/jats:styled-content>. US<\/jats:styled-content> and MIBI<\/jats:styled-content> localization studies matched in 76%, whereas 10\u00b77% had positive MIBI<\/jats:styled-content> only and 8\u00b73% US<\/jats:styled-content> only. Studies were negative in 3\u00b76% and contradictory in 1\u00b78%. Minimally invasive parathyroidectomy was performed in 87% of the matched group and 89% of the MIBI<\/jats:styled-content>\u2010only group. Surgical success rate, defined as postoperative normalization of calcium and PTH<\/jats:styled-content> levels, was similar in patients with a single positive study (MIBI<\/jats:styled-content> or US<\/jats:styled-content>) vs<\/jats:italic> double\u2010matched studies (MIBI<\/jats:styled-content> and US<\/jats:styled-content>). Patients were followed up for 6\u00a0weeks. Overall, pathology was consistent with adenoma in 95%.<\/jats:p><\/jats:sec>Discussion<\/jats:title>Parathyroidectomy success rate was similar in patients with primary HPT<\/jats:styled-content> and MIBI<\/jats:styled-content>\u2010only or US<\/jats:styled-content>\u2010only positive localization studies compared to those with matched US<\/jats:styled-content>\/MIBI<\/jats:styled-content> studies. The results support a clinical algorithm in which positive results from one imaging technique, either MIBI<\/jats:styled-content> or US<\/jats:styled-content>, are sufficient to refer a patient for parathyroid surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12835","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T15:03:11Z","timestamp":1433602991000},"page":"733-738","source":"Crossref","is-referenced-by-count":17,"title":["Parathyroid surgery: correlation between pre\u2010operative localization studies and surgical outcomes"],"prefix":"10.1111","volume":"83","author":[{"given":"Yaniv","family":"Ebner","sequence":"first","affiliation":[{"name":"Department of ENT, Head & Neck Surgery Meir Medical Center Kfar Saba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Garti\u2010Gross","sequence":"additional","affiliation":[{"name":"Department of ENT, Head & Neck Surgery Meir Medical Center Kfar Saba 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Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pnina","family":"Rotman\u2010Pikielny","sequence":"additional","affiliation":[{"name":"Department of Medicine E Meir Medical Center Kfar Saba Israel"},{"name":"Department of Endocrinology Meir Medical Center Kfar Saba Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.5858\/2008-132-1251-PHACP","article-title":"Primary hyperparathyroidism: a current perspective","volume":"132","author":"DeLellis R.A.","year":"2008","journal-title":"Archives of Pathology & Laboratory 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