{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:19:40Z","timestamp":1790086780250,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D toxicity, often considered rare, can be life\u2010threatening and associated with substantial morbidity, if not identified promptly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe clinical and biochemical features, risk factors and management of patients with vitamin D toxicity seen between January 2011 and January 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Patients presenting with vitamin D toxicity, between January 2011 and January 2013, at single tertiary care centre in Delhi\u2010NCR, India, were included. Evaluation included detailed clinical history and biochemical tests including serum calcium, phosphorus, creatinine, intact parathyroid hormone and 25\u2010hydroxyvitamin D (25(OH)D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen patients with vitamin D toxicity could be identified. Clinical manifestations included nausea, vomiting, altered sensorium, constipation, pancreatitis, acute kidney injury and weight loss. Median (range) age was 64\u00b75 (42\u201386) years. Median (range) serum 25(OH)D level and median (range) serum total serum calcium level were 371 (175\u20131161) ng\/ml and 13\u00b70 (11\u00b71\u201315\u00b77) mg\/dl, respectively. Overdose of vitamin D caused by prescription of mega\u2010doses of vitamin D was the cause of vitamin D toxicity in all cases. Median (range) cumulative vitamin D dose was 3\u00a0600\u00a0000 (2\u00a0220\u00a0000\u20136\u00a0360\u00a0000) IU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrate an emergence of vitamin D toxicity as an increasingly common cause of symptomatic hypercalcaemia. Irrational use of vitamin D in mega\u2010doses resulted in vitamin D toxicity in all cases. Awareness among healthcare providers regarding the toxic potential of high doses of vitamin D and cautious use of vitamin D supplements is the key to prevent this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12836","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T15:31:09Z","timestamp":1433604669000},"page":"327-331","source":"Crossref","is-referenced-by-count":83,"title":["Vitamin D toxicity resulting from overzealous correction of vitamin D deficiency"],"prefix":"10.1111","volume":"83","author":[{"given":"Parjeet","family":"Kaur","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes Medanta, the Medicity Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes Medanta, the Medicity Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambrish","family":"Mithal","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes Medanta, the Medicity Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-0954-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513001840"},{"key":"e_1_2_7_4_1","first-page":"917","article-title":"Unusual cases of chronic intoxication by vitamin D","volume":"16","author":"Chiricone D.","year":"2003","journal-title":"Journal of Nephrology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204303261801"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc063341"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450115"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.14.9.1188"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2007.08.005"},{"key":"e_1_2_7_10_1","unstructured":"Ross A.C. Taylor C.L. Yaktine A.L.et\u00a0al. editors. (2011)Dietary Reference Intakes for Calcium and Vitamin D. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Washington (DC): National Academies Press (US). Available from:http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK56070\/(accessed 3 January 2015)."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.5.842"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(38)80162-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3655"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.2.582S"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2530"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1238"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmp020"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2011.49"},{"key":"e_1_2_7_19_1","first-page":"118","article-title":"\u201cExcess gooD can be Dangerous\u201d. A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D","volume":"9","author":"Pandita K.K.","year":"2012","journal-title":"Clinical Cases in Mineral and Bone Metabolism: The Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.93773"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12836","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:24:39Z","timestamp":1695511479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/cen.12836"],"URL":"https:\/\/doi.org\/10.1111\/cen.12836","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}