{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:48:31Z","timestamp":1764510511377},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jiangsu Provincial Bureau of Health Foundation","award":["# H201356"],"award-info":[{"award-number":["# H201356"]}]},{"name":"International Exchange Program and Jiangsu Six Talent Peaks Program","award":["#2013-WSN-013"],"award-info":[{"award-number":["#2013-WSN-013"]}]},{"name":"Xuzhou Outstanding Medical Academic Leader Project and Xuzhou Science and Technology Grants","award":["#XM13B066","#KC14SX013","#KC14SH"],"award-info":[{"award-number":["#XM13B066","#KC14SX013","#KC14SH"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Insulin secretion and insulin resistance, which affect metabolic homoeostasis, each have a significant genetic component. Cyclin\u2010 dependent kinase 5 (<jats:styled-content style=\"fixed-case\">CDK<\/jats:styled-content>5) regulatory subunit\u2010associated protein 1\u2010like 1 (<jats:styled-content style=\"fixed-case\">CDKAL<\/jats:styled-content>1) rs10946398, a novel body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>)\u2010associated locus specifically in the Asian population, may impair insulin secretion and may be associated with insulin resistance and type 2 diabetes<jats:bold>.<\/jats:bold> Our objective was to investigate the impact of the rs10946398 polymorphism of <jats:styled-content style=\"fixed-case\">CDKAL<\/jats:styled-content>1 on insulin secretion, insulin resistance and glucose\u2010related traits in the Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>The study samples were based on a community\u2010based health examination survey conducted in central China. Indices of insulin resistance and insulin secretion were derived from fasting glucose measurements and oral glucose tolerance tests (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>s). Using multivariate linear regression models, the relationships between the rs10946398 polymorphism of <jats:styled-content style=\"fixed-case\">CDKAL<\/jats:styled-content>1 and insulin secretion, insulin resistance and quantitative glucose\u2010related traits were investigated in 2313 participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CDKAL<\/jats:styled-content>1 rs10946398 C allele showed a significant association with decreased insulin secretion (\u03b2\u00a0=\u00a0\u22120\u00b705, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70005), but not with insulin resistance (\u03b2\u00a0=\u00a00\u00b702, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b708). We also found that the <jats:styled-content style=\"fixed-case\">CDKAL<\/jats:styled-content>1 rs10946398 C allele was significantly associated with glucose\u2010related traits (fasting glucose, fasting insulin, 2\u2010h glucose and HbA1c). There was no significant relationship between rs10946398 and other metabolic traits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>rs10946398 of <jats:styled-content style=\"fixed-case\">CDKAL<\/jats:styled-content>1 was associated with markers of impaired insulin secretion. It is reasonable to infer that the relationship between <jats:styled-content style=\"fixed-case\">CDKAL<\/jats:styled-content>1 and metabolic diseases is mediated by its effect on glucose\u2010related traits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12838","type":"journal-article","created":{"date-parts":[[2015,6,28]],"date-time":"2015-06-28T12:12:51Z","timestamp":1435493571000},"page":"651-655","source":"Crossref","is-referenced-by-count":16,"title":["The <scp>CDKAL<\/scp>1 gene is associated with impaired insulin secretion and glucose\u2010related traits: the Cardiometabolic Risk in Chinese (CRC) study"],"prefix":"10.1111","volume":"83","author":[{"given":"Jun","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Xuzhou Central Hospital The Affiliated XuZhou Hospital of Medical College of Southeast University Xuzhou Jiangsu China"},{"name":"Xuzhou Institute of Medical Sciences Xuzhou Institute of Diabetes Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Pei","sequence":"additional","affiliation":[{"name":"School of Medicine Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuekui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xuzhou Central Hospital The Affiliated XuZhou Hospital of Medical College of Southeast University Xuzhou Jiangsu China"},{"name":"Xuzhou Institute of Medical Sciences Xuzhou Institute of Diabetes Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Sun","sequence":"additional","affiliation":[{"name":"Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xuzhou Central Hospital The Affiliated XuZhou Hospital of Medical College of Southeast University Xuzhou Jiangsu China"},{"name":"Xuzhou Institute of Medical Sciences Xuzhou Institute of Diabetes Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.07.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1087"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4238\/vol9-2gmr802"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093193"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03665.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.175"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0117"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0736"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0299-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049055"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2218"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399810666140214093600"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1319"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12201"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1583"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3047-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1141-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009153"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0047"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq281"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12025"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1086"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0374"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1790-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0506"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58056"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ11-0099"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.33549\/physiolres.932228","article-title":"Variation in CDKAL1 gene is associated with therapeutic response to sulphonylureas","volume":"61","author":"Schroner Z.","year":"2012","journal-title":"Physiological Research"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-97"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12838","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:22:22Z","timestamp":1695547342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,22]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/cen.12838"],"URL":"https:\/\/doi.org\/10.1111\/cen.12838","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,22]]}}}