{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:20:54Z","timestamp":1761513654351},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Eli Lilly"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether characteristics and outcomes of Italian patients in the observational global Hypopituitary Control and Complication Study (Hypo<jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>) differed according to the degree of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> deficiency (<jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Patients were grouped by tertiles of stimulated <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> peak concentration at baseline (Group A lowest tertile, <jats:italic>n<\/jats:italic>\u00a0=\u00a0342; Group B middle tertile, <jats:italic>n<\/jats:italic>\u00a0=\u00a0345; Group C highest tertile, <jats:italic>n<\/jats:italic>\u00a0=\u00a0338).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline demographics, lipid levels, body mass index categories and mean Framingham cardiovascular risk indexes were similar in the three groups and remained substantially unchanged over time, with no subsequent significant between\u2010group differences (except mean levels of triglycerides increased in the highest tertile group). <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> was adult\u2010onset for &gt;75% of patients in all groups. The percentage of patients with multiple pituitary deficiencies was higher in Group A than in the other groups; isolated <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> was reported with highest frequency in Group C. Patients in Group A received the lowest mean starting dose of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>. Hyperlipidaemia at baseline was reported in 35\u00b71%, 31\u00b71% and 24\u00b77% of patients in groups A, B and C, respectively (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7029). Mean duration of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> treatment was 7\u00b721, 5\u00b745 and 4\u00b796\u00a0years, respectively. The proportion of patients with adverse events did not differ significantly between groups, with a low prevalence over time of diabetes and cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Italian patients from Hypo<jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>, the level of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> deficit did not influence changes over time in metabolic parameters or adverse event profile, despite differences in <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> severity at baseline and in the starting <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> dose.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12839","type":"journal-article","created":{"date-parts":[[2015,6,28]],"date-time":"2015-06-28T12:13:03Z","timestamp":1435493583000},"page":"527-535","source":"Crossref","is-referenced-by-count":4,"title":["Characteristics and outcomes of Italian patients from the observational, multicentre, hypopituitary control and complications study (Hypo<scp>CCS<\/scp>) according to tertiles of growth hormone peak concentration following stimulation testing at study entry"],"prefix":"10.1111","volume":"83","author":[{"given":"Marco","family":"Losa","sequence":"first","affiliation":[{"name":"IRCCS San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Beck\u2010Peccoz","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS C\u00e0 Granda Policlinico University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Aimaretti","sequence":"additional","affiliation":[{"name":"University of Eastern Piedmont Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Di Somma","sequence":"additional","affiliation":[{"name":"IRCCS SDN Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosaria","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"University of Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Ferone","sequence":"additional","affiliation":[{"name":"University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Giampietro","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore M.","family":"Corsello","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Poggi","sequence":"additional","affiliation":[{"name":"S. 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