{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:05:55Z","timestamp":1774375555384,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with idiopathic hypoparathyroidism (IH) require variable doses of calcium and 1\u2010\u03b1\u2010(OH)D. The reasons for such variability are not clear. As autoimmune mechanisms may play a role in IH, there is a possibility of coexistent coeliac disease with calcium\/vitamin D malabsorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We assessed the prevalence of coeliac disease and antitissue transglutaminase autoantibodies (anti\u2010tTGAbs) in IH and analysed the effect of a gluten\u2010free diet on calcaemic control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 171 patients with IH and 126 healthy controls were screened for anti\u2010tTGAb. IH patients with anti\u2010tTGAb &gt;20\u00a0RU\/ml underwent duodenoscopy and intestinal biopsy; those with biopsy\u2010proven coeliac disease were followed up on a gluten\u2010free diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven of 171 (6\u00b74%) patients with IH and seven of 126 (5\u00b76%) controls had anti\u2010tTGAb (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b781). There was no difference in the clinical and biochemical parameters at diagnosis and during long\u2010term follow\u2010up of 7\u00b72\u00a0\u00b1\u00a04\u00b78\u00a0year (mean serum total calcium\u00a0=\u00a01\u00b788\u00a0\u00b1\u00a00\u00b716 <jats:italic>vs<\/jats:italic> 1\u00b782\u00a0\u00b1\u00a00\u00b736\u00a0mmol\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b752; phosphorus = 1\u00b781\u00a0\u00b1\u00a00\u00b717 <jats:italic>vs<\/jats:italic> 1\u00b787\u00a0\u00b1\u00a00\u00b736\u00a0mmol\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b753) in IH patients with and without anti\u2010tTGAb. Although CaSRAb positivity was comparable in the two groups, IH patients with anti\u2010tTGAb had higher TPOAb positivity (45\u00b75% <jats:italic>vs<\/jats:italic> 12\u00b78%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702). Coeliac disease was diagnosed in only 2\/9 patients with IH on biopsy, both of whom showed improved calcaemic control with a gluten\u2010free diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of coeliac autoimmunity (6\u00b74%) and coeliac disease (1\u00b72%) in patients with IH seems to be similar to that in the general population. Notwithstanding this modest prevalence, it is important to be aware of the potential occurrence of coeliac disease with IH and the beneficial effect of a gluten\u2010free diet on calcium control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12850","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T12:21:34Z","timestamp":1436185294000},"page":"578-586","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of coeliac disease in idiopathic hypoparathyroidism and effect of gluten\u2010free diet on calcaemic control"],"prefix":"10.1111","volume":"84","author":[{"given":"Soma","family":"Saha","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savita","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Paediatrics All India Institute of Medical Sciences New Delhi 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