{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T19:13:04Z","timestamp":1772392384316,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007052","name":"Universit\u00e0 degli Studi di Verona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Limited literature has shown that maximal oxygen consumption (V'O<jats:sub>2max<\/jats:sub>), that is the maximal capacity of an individual to perform aerobic work, may be lowered in overweight\/obese women with polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>). However, it remains unclear whether this impairment is associated with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> <jats:italic>per se<\/jats:italic> or is entirely due to body fat excess. Our objective was to assess whether cardiorespiratory fitness is altered in normal\u2010weight <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women and to investigate which factors are associated with this phenomenon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Fifteen normal\u2010weight <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women and 15 age\u2010 and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010matched healthy controls. Fourteen subjects in each group completed the protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>V'O<jats:sub>2max<\/jats:sub> and ventilatory thresholds (maximal incremental cycle ergometer test with breath\u2010by\u2010breath analysis of gas exchange), insulin sensitivity (hyperinsulinaemic euglycaemic clamp) and androgenaemia (serum total and free testosterone, measured by liquid chromatography mass spectrometry and equilibrium dialysis) were accurately assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maximal V'O<jats:sub>2<\/jats:sub> and power were strikingly impaired in normal\u2010weight <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> individuals, as compared with healthy controls (29\u00b74\u00a0\u00b1\u00a01\u00b75 <jats:italic>vs<\/jats:italic> 35\u00b78\u00a0\u00b1\u00a01\u00b76\u00a0ml O<jats:sub>2<\/jats:sub>\/kg\/min, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008; 138\u00a0\u00b1\u00a06 <jats:italic>vs<\/jats:italic> 170\u00a0\u00b1\u00a010\u00a0W, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7011, respectively). Similarly, oxygen consumption and power at both the first and second ventilatory thresholds were significantly lower in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> subjects than in healthy women. In multiple regression analysis, V'O<jats:sub>2max<\/jats:sub> was negatively predicted by serum\u2010free testosterone levels, but not by body fat mass and glucose disposal rate (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00\u00b745 <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cardiorespiratory fitness is impaired in normal\u2010weight <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women. Androgen excess but not insulin sensitivity is associated with this alteration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12855","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T12:15:24Z","timestamp":1436962524000},"page":"895-901","source":"Crossref","is-referenced-by-count":8,"title":["Serum testosterone predicts cardiorespiratory fitness impairment in normal\u2010weight women with polycystic ovary syndrome"],"prefix":"10.1111","volume":"83","author":[{"given":"Elisabetta","family":"Bacchi","sequence":"first","affiliation":[{"name":"Unit of Endocrinology, Diabetes and Metabolism University and Azienda Ospedaliera Universitaria Integrata of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Negri","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Diabetes and Metabolism University and Azienda Ospedaliera Universitaria Integrata of Verona Verona 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