{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:06:08Z","timestamp":1791234368175,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202127"],"award-info":[{"award-number":["81202127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["Y14H160065"],"award-info":[{"award-number":["Y14H160065"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>It remains controversial whether or not the aggressiveness of familial nonmedullary thyroid cancer (FNMTC) differs from sporadic carcinoma. The aim of this study was to determine the clinicopathological features and prognosis of FNMTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A matched\u2010case comparative study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and seventy\u2010two patients with familial papillary thyroid carcinoma (FPTC) were enrolled as the study group, and another 372 patients with sporadic PTC were enrolled as controls and matched for gender, age, tumour\/node\/metastasis (TNM) staging and approximate duration of follow\u2010up. We compared the differences in the clinicopathological features and prognosis between the subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with sporadic PTC, patients with FPTC were more likely to present tumour multicentricity, bilateral growth and a concomitant nodular goitre (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). In papillary thyroid microcarcinoma (PTMC), a higher recurrence rate was noted in patients with a family history of PTC, and this remained independently predictive on multivariate analysis. The patients with FPTC in the second generation showed an earlier age of onset, more frequent Hashimoto's thyroiditis and a higher recurrence rate than the first generation, while the first\u2010generation offspring of patients had a higher incidence of nodular goitre than the second generation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of familial history in PTC indicates an increase in biological aggressiveness, and patients in the second generation may exhibit the \u2018genetic anticipation\u2019 phenomenon. At present, the available data are not sufficient to support a more aggressive approach for FPTC. However, a family history of PTC is an independent risk factor for recurrence in patients with PTMC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12859","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T15:27:34Z","timestamp":1437406054000},"page":"598-606","source":"Crossref","is-referenced-by-count":37,"title":["Clinicopathological features and prognosis of familial papillary thyroid carcinoma \u2013 a large\u2010scale, matched, case\u2013control study"],"prefix":"10.1111","volume":"84","author":[{"given":"Jun","family":"Cao","sequence":"first","affiliation":[{"name":"The Affiliated Tumor Hospital of Zhejiang Chinese Medical University Hangzhou China"},{"name":"Department of Head and Neck Surgery Zhejiang Province Cancer Hospital Gongshu District Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Chen","sequence":"additional","affiliation":[{"name":"The Affiliated Tumor Hospital of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Zhejiang Province Cancer Hospital Gongshu District Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Zhejiang Province Cancer Hospital Gongshu District Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hua","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Zhejiang Province Cancer Hospital Gongshu District Hangzhou 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