{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:09:59Z","timestamp":1771031399039,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370467"],"award-info":[{"award-number":["81370467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["csct2011jjzt0100"],"award-info":[{"award-number":["csct2011jjzt0100"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine serum vascular endothelial growth factor B (VEGF\u2010B) levels in polycystic ovary syndrome, their association with insulin resistance and \u03b2\u2010cell dysfunction, and the effect of metformin on serum VEGF\u2010B levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional, interventional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>We recruited 103 women with polycystic ovary syndrome and 96 age\u2010matched healthy controls. Serum VEGF\u2010B levels were determined in all participants, and 44 polycystic ovary syndrome patients randomly received metformin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>We measured VEGF\u2010B levels in healthy controls and women with polycystic ovary syndrome before and after metformin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with polycystic ovary syndrome had higher serum VEGF\u2010B levels, which decreased with metformin treatment. In the lean and overweight\/obese groups, patients with polycystic ovary syndrome had higher plasma VEGF\u2010B levels than did healthy controls (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). VEGF\u2010B levels were correlated with body mass index, body fat percentage, <jats:italic>M<\/jats:italic> values, homeostasis model assessment of insulin resistance and \u03b2\u2010cell function indices. A multiple linear regression analysis showed that VEGF\u2010B level was associated with <jats:italic>M<\/jats:italic> values after adjusting for age, body mass index, serum sex hormones and serum lipids in women with polycystic ovary syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum VEGF\u2010B is significantly higher in women with polycystic ovary syndrome and is closely and positively related to insulin resistance. Metformin treatment reduces VEGF\u2010B levels and ameliorates insulin resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12950","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T11:00:56Z","timestamp":1442833256000},"page":"386-393","source":"Crossref","is-referenced-by-count":20,"title":["Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment"],"prefix":"10.1111","volume":"84","author":[{"given":"Feifei","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gangyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Chongqing Traditional Chinese Medicine Hospital Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Queensland Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1911"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11464"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1151"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08945"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Insulin resistance and polycystic ovary syndrome","volume":"53","author":"Dewailly D.","year":"1992","journal-title":"Annales 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