{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:02:03Z","timestamp":1791291723366,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Heilongjiang Provincial Government Medical Science","award":["H201392"],"award-info":[{"award-number":["H201392"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n The objective of this study was to determine the levels of thrombospondin\u20101 (\n TSP<\/jats:styled-content>\n \u20101), transforming growth factor\u2010\u03b21 (\n TGF<\/jats:styled-content>\n \u2010\u03b21) and nuclear factor kappa\u03b2 (\n NF<\/jats:styled-content>\n \u2010\u03ba\u03b2) in polycystic ovarian syndrome (\n PCOS<\/jats:styled-content>\n ) patients with and without insulin resistance and after treatment with cyproterone acetate\/ethinyloestradiol with or without concomitant metformin.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n \n Patients with\n PCOS<\/jats:styled-content>\n and healthy women were recruited. Patients were subdivided into obese and nonobese based on body mass index. Patients with\n PCOS<\/jats:styled-content>\n were also grouped according to homoeostasis model assessment\u2010insulin resistance (\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n ) \u22652\u00b769 or <2\u00b769, and by\n PCOS<\/jats:styled-content>\n phenotype. Patients with\n PCOS<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n were treated with a 6\u2010month course of cyproterone acetate\/ethinyloestradiol with or without concomitant metformin.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n Inflammatory markers were examined at baseline, and after 6 months of treatment.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 445 women with\n PCOS<\/jats:styled-content>\n (mean age 25\u00b79 \u00b1 2\u00b77 years; 298 obese, 147 nonobese) and 213 normal controls (mean age 24\u00b79 \u00b1 3\u00b70 years) were included. Regardless of obesity status, testosterone, free androgen index (\n FAI<\/jats:styled-content>\n ), luteinizing hormone\/follicle\u2010stimulating hormone (\n LH<\/jats:styled-content>\n \/\n FSH<\/jats:styled-content>\n ) ratio,\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n ,\n TSP<\/jats:styled-content>\n \u20101 and\n NF<\/jats:styled-content>\n \u2010\u03baB in the\n PCOS<\/jats:styled-content>\n groups were significantly higher than in the control group, whereas\n TSP<\/jats:styled-content>\n \u20101 was lower in the\n PCOS<\/jats:styled-content>\n groups (all,\n P<\/jats:italic>\n < 0\u00b705). Patients with\n PCOS<\/jats:styled-content>\n without\n IR<\/jats:styled-content>\n had lower\n TSP<\/jats:styled-content>\n \u20101 levels than control patients (\n P<\/jats:italic>\n < 0\u00b705). Treatment with cyproterone acetate\/ethinyloestradiol with addition of metformin reduced the level of\n NF<\/jats:styled-content>\n \u2010\u03baB,\n TGF<\/jats:styled-content>\n \u2010\u03b21 and\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n and increased the level of\n TSP<\/jats:styled-content>\n \u20101.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These results support the association between\n PCOS<\/jats:styled-content>\n and chronic inflammation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.12951","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T06:09:10Z","timestamp":1442902150000},"page":"913-922","source":"Crossref","is-referenced-by-count":84,"title":["Serum levels of\n TSP<\/scp>\n \u20101,\n NF<\/scp>\n \u2010\u03baB and\n TGF<\/scp>\n \u2010\u03b21 in polycystic ovarian syndrome (\n PCOS<\/scp>\n ) patients in northern China suggest\n PCOS<\/scp>\n is associated with chronic inflammation"],"prefix":"10.1111","volume":"83","author":[{"given":"Meimei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Harbin Medical University Harbin Hei Longjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Harbin Medical University Harbin Hei Longjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Harbin Medical University Harbin Hei Longjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Harbin Medical University Harbin Hei Longjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Harbin Medical University Harbin Hei Longjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Affiliated Hospital of Hebei University Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changmin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Harbin Medical University Harbin Hei Longjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/gye.15.2.142.149"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1214"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.11.023"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-14-0435"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.01.025"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp131"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0686"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0840"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/296069"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2003.12.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.04.022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4167"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(00)00152-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3199-3"},{"key":"e_1_2_8_18_1","unstructured":"National Institutes of Health.Evidence\u2010based methodology workshop on polycystic ovary syndrome. December 3\u20135 2012. Executive summary. Available from:https:\/\/prevention.nih.gov\/docs\/programs\/pcos\/FinalReport.pdf(accessed 31082015)."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1034"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des463"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.02.052"},{"key":"e_1_2_8_22_1","first-page":"635","article-title":"Analysis of insulin release pattern in patients with polycystic ovary syndrome and normal glucose tolerance","volume":"28","author":"Lou X.Z.","year":"2012","journal-title":"Chinese Journal of Endocrinology and Metabolism"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.2.461S"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2327"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113485294"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1803"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(01)00147-7"},{"key":"e_1_2_8_28_1","first-page":"1281","article-title":"Thrombospondin in human glomerulopathies. A marker of inflammation and early fibrosis","volume":"144","author":"McGregor B.","year":"1994","journal-title":"American Journal of Pathology"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-007-0397-5"},{"key":"e_1_2_8_30_1","first-page":"3266","article-title":"Clinical features, hormonal profile, and metabolic abnormalities of obese women with obese polycystic ovary syndrome","volume":"85","author":"Li X.","year":"2005","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.1.201"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706435200"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.32.s3.3.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.8009"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590802288242"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.06.035"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12951","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.12951","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T20:57:02Z","timestamp":1692392222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,19]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/cen.12951"],"URL":"https:\/\/doi.org\/10.1111\/cen.12951","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,19]]}}}