{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:40:11Z","timestamp":1791819611197,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n Although an International Workshop has suggested that cardiovascular assessment in asymptomatic primary hyperparathyroidism (\n PHPT<\/jats:styled-content>\n ) patients is not necessary, improvements in risk factors of subclinical atherosclerosis have been shown following parathyroidectomy. The objectives of this study were to determine whether parathyroidectomy in asymptomatic\n PHPT<\/jats:styled-content>\n patients causes any change in carotid intima\u2010media thickness (\n CIMT<\/jats:styled-content>\n ), arterial stiffness [pulse wave velocity (\n PWV<\/jats:styled-content>\n )] and soluble\n CD<\/jats:styled-content>\n 40 ligand (\n sCD<\/jats:styled-content>\n 40L) levels.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Prospective study evaluating female patients diagnosed with asymptomatic\n PHPT<\/jats:styled-content>\n in a single centre over a 6\u2010month period.\n <\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n \n A total of 48 subjects were included: 17 hypercalcaemic (\n HC<\/jats:styled-content>\n , mean age: 51 \u00b1 8 years, Ca: 2\u00b773 \u00b1 0\u00b717 mmol\/l) and 16 normocalcaemic (\n NC<\/jats:styled-content>\n , mean age: 58 \u00b1 7 years, Ca: 2\u00b730 \u00b1 0\u00b710 mmol\/l)\n PHPT<\/jats:styled-content>\n patients, and 15 healthy controls (mean age: 52 \u00b1 4 years, Ca: 2\u00b727 \u00b1 0\u00b707 mmol\/l).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Biochemical tests,\n CIMT<\/jats:styled-content>\n ,\n PWV<\/jats:styled-content>\n and\n sCD<\/jats:styled-content>\n 40L levels were compared at baseline and 6 months after parathyroidectomy (\n PT<\/jats:styled-content>\n x).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At baseline,\n CIMT<\/jats:styled-content>\n and\n PWV<\/jats:styled-content>\n values in the\n HC<\/jats:styled-content>\n and\n NC<\/jats:styled-content>\n patients were higher than in the control group. While there was a significant reduction in\n CIMT<\/jats:styled-content>\n (601 \u00b1 91 \u03bcm\n vs<\/jats:italic>\n 541 \u00b1 65 \u03bcm,\n P<\/jats:italic>\n = 0\u00b7006) and\n PWV<\/jats:styled-content>\n (9\u00b76 \u00b1 1\u00b78\n vs<\/jats:italic>\n 8\u00b74 \u00b1 1\u00b75 m\/s,\n P<\/jats:italic>\n = 0\u00b7000) in the hypercalcaemic group at the end of the 6th month after\n PT<\/jats:styled-content>\n x, no change was observed in normocalcaemic group (\n P<\/jats:italic>\n = 0\u00b7686 and\n P<\/jats:italic>\n = 0\u00b7196 respectively). No differences were observed in\n sCD<\/jats:styled-content>\n 40L levels between patient and control groups or between baseline and 6 months in patients undergoing parathyroidectomy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Parathyroidectomy leads to an improvement in the structural and functional impairment associated with atherosclerosis in the vascular wall in asymptomatic hypercalcaemic\n PHPT<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.12952","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T01:40:43Z","timestamp":1443058843000},"page":"39-47","source":"Crossref","is-referenced-by-count":40,"title":["Parathyroidectomy in asymptomatic primary hyperparathyroidism reduces carotid intima\u2010media thickness and arterial stiffness"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-1103","authenticated-orcid":false,"given":"G\u00fcven Bar\u0131\u015f","family":"Cansu","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Yunusemre State Hospital Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nusret","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism \u015e\u0131rnak State Hospital \u015e\u0131rnak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebahat","family":"\u00d6zdem","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Medicine Akdeniz University Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Kemal","family":"Balc\u0131","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism School of Medicine Akdeniz University Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcltekin","family":"S\u00fcleymanlar","sequence":"additional","affiliation":[{"name":"Division of Nephrology School of Medicine Akdeniz University Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cumhur","family":"Ar\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of General Surgery School of Medicine Akdeniz University Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Boz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine School of Medicine Akdeniz University Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Sar\u0131","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism School of Medicine Akdeniz University Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Ali","family":"Altunba\u015f","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism School of Medicine Akdeniz University Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1413"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1415"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.232"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.05.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1760"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1109187"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833c8a1a"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2009.39.8.317"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200209000-00013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.579342"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.483628"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/408295"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1530\/EJE-12-0124","article-title":"Effect of parathyroidectomy on subclinical cardiovascular disease in mild primary hyperparathyroidism","volume":"167","author":"Walker M.D.","year":"2012","journal-title":"European Journal of Endocrinology"},{"key":"e_1_2_7_15_1","first-page":"887","article-title":"Intima\u2010media thickness measurement of the carotid artery in patients with primary hyperparathyroidism. 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