{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:03:12Z","timestamp":1782363792843,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T00:00:00Z","timestamp":1445385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novartis Farma"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Acromegaly, a disease caused by <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I hypersecretion, is associated with a high mortality rate; early recognition is therefore necessary to ensure successful treatment and to avoid comorbidities. We have created a symptom\/sign scoring tool (<jats:styled-content style=\"fixed-case\">ACROSCORE<\/jats:styled-content>) for physicians to use to identify acromegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>To compare cases of acromegaly diagnosed between 1990 and 2014 against a control group affected by non\u2010<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\u2010secreting pituitary tumours to identify symptoms and signs that are most discriminative for acromegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Confirmed acromegaly patients and patients affected by non\u2010<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\u2010secreting pituitary tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>In all patients, signs, symptoms and comorbidities were recorded from medical records and collected using a specifically designed questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 194 acromegaly patients [115 women; mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) age 47\u00b72 (14\u00b72) years] and 243 patients affected by non\u2010<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\u2010secreting pituitary tumours [131 women; mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) age 45\u00b78 (15\u00b78) years] were included. A strong association was observed for type 2\/secondary diabetes [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 3\u00b77], hyperhidrosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6\u00b71), thyroid hyperplasia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 13\u00b79), colorectal polyps (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 10\u00b74), spaced teeth (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 25\u00b74) and carpal tunnel syndrome (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4\u00b73). Based on this information, a multivariable logistic model was built and a 14\u2010point scoring system developed. A score of 0 excludes the risk of acromegaly [positive predictive value (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content><jats:sup>+<\/jats:sup>) = 0\u00b76%]; scores 1\u20135 comprise a grey area; scores &gt;5 indicate that a diagnosis of acromegaly cannot be excluded (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content><jats:sup>+<\/jats:sup> = 46\u00b71%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Once validated in independent studies, <jats:styled-content style=\"fixed-case\">ACROSCORE<\/jats:styled-content> may represent a new tool for the clinical screening of acromegaly that can be used by general practitioners and nonendocrinology specialists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12959","type":"journal-article","created":{"date-parts":[[2015,10,3]],"date-time":"2015-10-03T12:58:47Z","timestamp":1443877127000},"page":"380-385","source":"Crossref","is-referenced-by-count":32,"title":["<scp>ACROSCORE<\/scp>: a new and simple tool for the diagnosis of acromegaly, a rare and underdiagnosed disease"],"prefix":"10.1111","volume":"84","author":[{"given":"Nunzia","family":"Prencipe","sequence":"first","affiliation":[{"name":"Department of Medical Science Division of Endocrinology, Diabetology and Metabolism Citt\u00e0 della Salute e della Scienza di Torino University of Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Floriani","sequence":"additional","affiliation":[{"name":"Department of Oncology IRCCS Istituto di Ricerche Farmacologiche Mario Negri Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Guaraldi","sequence":"additional","affiliation":[{"name":"Department of Medical Science Division of Endocrinology, Diabetology and Metabolism Citt\u00e0 della Salute e della Scienza di Torino University of Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stellina V.","family":"Di Giacomo","sequence":"additional","affiliation":[{"name":"Department of Medical Science Division of Endocrinology, Diabetology and Metabolism Citt\u00e0 della Salute e della Scienza di Torino University of Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cannavo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Arnaldi","sequence":"additional","affiliation":[{"name":"Endocrinology Division Department of Clinical and Molecular Sciences Politecnica delle Marche University Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Berton","sequence":"additional","affiliation":[{"name":"Department of Medical Science Division of Endocrinology, Diabetology and Metabolism Citt\u00e0 della Salute e della Scienza di 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