{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:55:52Z","timestamp":1789181752755,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T00:00:00Z","timestamp":1447632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA195547\u201001"],"award-info":[{"award-number":["U01CA195547\u201001"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Summary<\/jats:title>\n \n Objectives<\/jats:title>\n \n To estimate the prevalence of central precocious puberty (\n CPP<\/jats:styled-content>\n ) after treatment for tumours and malignancies involving the central nervous system (\n CNS<\/jats:styled-content>\n ) and examine repercussions on growth and pubertal outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Retrospective study of patients with tumours near and\/or exposed to radiotherapy to the hypothalamus\/pituitary axis (\n HPA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Measurements<\/jats:title>\n \n Patients with\n CPP<\/jats:styled-content>\n were evaluated at puberty onset, completion of Gn\n RH<\/jats:styled-content>\n agonist treatment (Gn\n RH<\/jats:styled-content>\n a) and last follow\u2010up. Multivariable analysis was used to test associations between tumour location, sex, age at\n CPP<\/jats:styled-content>\n , Gn\n RH<\/jats:styled-content>\n a duration and a diagnosis of\n CPP<\/jats:styled-content>\n with final height <\u20102\n SD<\/jats:styled-content>\n score (\n SDS<\/jats:styled-content>\n ), gonadotropin deficiency (\n LH<\/jats:styled-content>\n \/\n FSHD<\/jats:styled-content>\n ) and obesity, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eighty patients (47 females) had\n CPP<\/jats:styled-content>\n and were followed for 11\u00b74 \u00b1 5\u00b70 years (mean \u00b1\n SD<\/jats:styled-content>\n ). The prevalence of\n CPP<\/jats:styled-content>\n was 15\u00b72% overall, 29\u00b72% following\n HPA<\/jats:styled-content>\n tumours and 6\u00b76% after radiotherapy for non\u2010\n HPA<\/jats:styled-content>\n tumours. Height <\u20102\n SDS<\/jats:styled-content>\n was more common at the last follow\u2010up than at the puberty onset (21\u00b74%\n vs<\/jats:italic>\n 2\u00b74%,\n P<\/jats:italic>\n = 0\u00b7005). Obesity was more prevalent at the last follow\u2010up than at the completion of Gn\n RH<\/jats:styled-content>\n a or the puberty onset (37\u00b77%, 22\u00b76% and 20\u00b78%, respectively,\n P<\/jats:italic>\n = 0\u00b703). Longer duration of Gn\n RH<\/jats:styled-content>\n a was associated with increased odds of final height <\u20102\n SDS<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n = 2\u00b71, 95%\n CI<\/jats:styled-content>\n 1\u00b70\u20134\u00b73) and longer follow\u2010up with obesity (\n OR<\/jats:styled-content>\n = 1\u00b73, 95%\n CI<\/jats:styled-content>\n 1\u00b71\u20131\u00b76).\n LH<\/jats:styled-content>\n \/\n FSHD<\/jats:styled-content>\n was diagnosed in 32\u00b76%. There was no independent association between\n CPP<\/jats:styled-content>\n and final height <\u20102\n SDS<\/jats:styled-content>\n , and\n LH<\/jats:styled-content>\n \/\n FSHD<\/jats:styled-content>\n and obesity in the subset of patients with\n HPA<\/jats:styled-content>\n low\u2010grade gliomas.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients with organic\n CPP<\/jats:styled-content>\n experience an incomplete recovery of growth and a high prevalence of\n LH<\/jats:styled-content>\n \/\n FSHD<\/jats:styled-content>\n and obesity. Early diagnosis and treatment of\n CPP<\/jats:styled-content>\n may limit further deterioration of final height prospects.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.12964","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T04:11:06Z","timestamp":1444795866000},"page":"361-371","source":"Crossref","is-referenced-by-count":54,"title":["Central precocious puberty following the diagnosis and treatment of paediatric cancer and central nervous system tumours: presentation and long\u2010term outcomes"],"prefix":"10.1111","volume":"84","author":[{"given":"Wassim","family":"Chemaitilly","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Pediatric Medicine St. Jude Children's Research Hospital Memphis TN USA"},{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Barnes","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Pediatric Medicine St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN USA"},{"name":"Division of Cancer Survivorship Department of Oncology St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Hon","family":"Pui","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry E.","family":"Kun","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie L.","family":"Robison","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN 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