{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:14:39Z","timestamp":1777976079166,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novartis Finland Oyj"},{"name":"Helsinki University Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The published data on health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) after treatment of nonfunctioning pituitary adenomas (<jats:styled-content style=\"fixed-case\">NFPA<\/jats:styled-content>s) are conflicting. We evaluated <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in a recent series of patients who had surgery for an <jats:styled-content style=\"fixed-case\">NFPA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study including a large control population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Measurements<\/jats:title><jats:p>A <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL questionnaire (15D) was sent to all patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0161) having undergone transsphenoidal surgery for <jats:styled-content style=\"fixed-case\">NFPA<\/jats:styled-content> in the years 2000\u20132010 at the Helsinki University Hospital. The 15D score and dimension scores of the study population (<jats:italic>n<\/jats:italic>\u00a0=\u00a0137) were compared with those of a large (<jats:italic>n<\/jats:italic>\u00a0=\u00a04967) gender\u2010 and age\u2010standardized control population. Possible independent predictors of <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in the patients were estimated with multivariate regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postoperatively, 57% of the patients had normal visual function. After a mean follow\u2010up of 7\u00b74\u00a0\u00b1\u00a03\u00b72\u00a0years (mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>), 62% suffered from hypopituitarism. Overall, <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL was near\u2010normal in patients compared to controls (15D scores 0\u00b7885\u00a0\u00b1\u00a00\u00b7114 <jats:italic>vs<\/jats:italic> 0\u00b7903\u00a0\u00b1\u00a00\u00b7093, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b707). On single dimensions, patients had impaired vision and sexual activity (both <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70005), more depression and distress (both <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7005) and less discomfort and symptoms (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b705). Age, body mass index, diabetes, depression and reoperation were independent predictors of impaired <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b705). Thyroxine substitution was associated with impaired and hydrocortisone and testosterone substitution (males only) with better <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b705).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This recent series of <jats:styled-content style=\"fixed-case\">NFPA<\/jats:styled-content> patients demonstrates that overall <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL is near\u2010normal after medium term follow\u2010up; the most impaired dimensions were in vision and sexual activity. Comorbidities are strong predictors of impaired <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12967","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T06:22:46Z","timestamp":1445581366000},"page":"532-539","source":"Crossref","is-referenced-by-count":20,"title":["Health\u2010related quality of life in patients treated for nonfunctioning pituitary adenomas during the years 2000\u20132010"],"prefix":"10.1111","volume":"84","author":[{"given":"Atte","family":"Karppinen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Ritvonen","sequence":"additional","affiliation":[{"name":"Endocrinology Abdominal Center University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risto","family":"Roine","sequence":"additional","affiliation":[{"name":"Group Administration University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Department of Health and Social Management University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harri","family":"Sintonen","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satu","family":"Vehkavaara","sequence":"additional","affiliation":[{"name":"Endocrinology Abdominal Center University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Kivipelto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley B.","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Oxford Centre for Diabetes, Endocrinology &amp; Metabolism Churchill Hospital University of Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Schalin\u2010J\u00e4ntti","sequence":"additional","affiliation":[{"name":"Endocrinology Abdominal Center University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02326"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000327025.03975.BA"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(01)01101-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-015-0636-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1375"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0676"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0259"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0308"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0669"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1645"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03947.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2742"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026475531996"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002086"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002090"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-008-9317-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-014-0787-4"},{"key":"e_1_2_7_21_1","unstructured":"Koskinen S. 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