{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:56:00Z","timestamp":1789480560085,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In Europe, growth hormone (GH) treatment for children born small for gestational age (SGA) can only be initiated after 4 years of age. However, younger age at treatment initiation is a predictor of favourable response. To assess the effect of GH treatment on early growth and cognitive functioning in very young (&lt;30 months), short\u2010stature children born SGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A 2\u2010year, randomized controlled, multicentre study (NCT00627523; EGN study), in which patients received either GH treatment or no treatment for 24 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Children aged 19\u201329 months diagnosed as SGA at birth, and for whom sufficient early growth data were available, were eligible. Patients were randomized (1:1) to GH treatment (Genotropin<jats:sup>\u00ae<\/jats:sup>, Pfizer Inc.) at a dose of 0\u00b7035 mg\/kg\/day by subcutaneous injection, or no treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The primary objective was to assess the change from baseline in height standard deviation score (SDS) after 24 months of GH treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Change from baseline in height SDS was significantly greater in the GH treatment <jats:italic>vs<\/jats:italic> control group at both month 12 (1\u00b703 <jats:italic>vs<\/jats:italic> 0\u00b714) and month 24 (1\u00b763 <jats:italic>vs<\/jats:italic> 0\u00b743; both <jats:italic>P<\/jats:italic> &lt; 0\u00b7001). Growth velocity SDS was significantly higher in the GH treatment <jats:italic>vs<\/jats:italic> control group at 12 months (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001), but not at 24 months. There was no significant difference in mental or psychomotor development indices between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GH treatment for 24 months in very young short\u2010stature children born SGA resulted in a significant increase in height SDS compared with no treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12968","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T14:12:45Z","timestamp":1445868765000},"page":"353-360","source":"Crossref","is-referenced-by-count":5,"title":["A 2\u2010year multicentre, open\u2010label, randomized, controlled study of growth hormone (Genotropin<sup>\u00ae<\/sup>) treatment in very young children born small for gestational age: Early Growth and Neurodevelopment (EGN) Study"],"prefix":"10.1111","volume":"84","author":[{"given":"Jean","family":"De Schepper","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology Universitair Ziekenhuis Brussel Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Vanderfaeillie","sequence":"additional","affiliation":[{"name":"Faculty of Psychology and Educational Sciences Vrije Universiteit Brussel Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primus\u2010E.","family":"Mullis","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology Inselspital University Children's Hospital Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Rooman","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Universitair Ziekenhuis Antwerp Antwerpen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Robertson","sequence":"additional","affiliation":[{"name":"Biostatistics Quanticate Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Dilleen","sequence":"additional","affiliation":[{"name":"Pfizer Belgium Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Gomez","sequence":"additional","affiliation":[{"name":"Pfizer Belgium Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut A.","family":"Wollmann","sequence":"additional","affiliation":[{"name":"Pfizer Belgium Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"National Institute of Clinical Excellence(2010)NICE technology appraisals [TA188]."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000289570"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70006-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337570"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2010-494656"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01434.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199511000-00017"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200107000-00017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.1.111"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000185002"},{"key":"e_1_2_6_12_1","first-page":"716","article-title":"Neurocognitive development of children born small for gestational age (SGA). An update","volume":"9","author":"Puga B.","year":"2012","journal-title":"Pediatric Endocrinology Reviews"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031187"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02335"},{"key":"e_1_2_6_15_1","first-page":"1","article-title":"Physical growth of Swiss children from birth to 20 years of age. First Zurich longitudinal study of growth and development","volume":"52","author":"Prader A.","year":"1989","journal-title":"Helvetica Paediatrica Acta. Supplementum"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(86)80005-6"},{"key":"e_1_2_6_17_1","volume-title":"Bayley Scales of Infant Development\u2013Second Edition","author":"Bayley N.","year":"1993"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/J006v20n01_02","article-title":"Concurrent validity of the Bayley Scales of Infant Development II Motor Scale and the Peabody Developmental Motor Scales in two\u2010year\u2010old children","volume":"20","author":"Provost B.","year":"2000","journal-title":"Physical & Occupational Therapy in Pediatrics"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195909000-00030"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb00436.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.034785"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.6.1454"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01495.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0078"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1934"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2008.21.5.423"},{"key":"e_1_2_6_27_1","first-page":"184","article-title":"Craniofacial growth in short children born small for gestational age: two years follow\u2010up after high\u2010dose growth hormone treatment","volume":"17","author":"Erum R.","year":"1997","journal-title":"Journal of Craniofacial Genetics and Developmental Biology"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0152-L"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089324"},{"key":"e_1_2_6_30_1","first-page":"331","article-title":"The effect of growth hormone treatment on head circumference in growth hormone\u2010deficient children","volume":"50","author":"Darendeliler F.","year":"2008","journal-title":"Turkish Journal of Pediatrics"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.12.037"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.10.3786"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03504.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03224.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0049"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.06.034"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12968","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:38:53Z","timestamp":1695490733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,25]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/cen.12968"],"URL":"https:\/\/doi.org\/10.1111\/cen.12968","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,25]]}}}