{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:11:51Z","timestamp":1791893511051,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There are limited data concerning the evolution of radiation\u2010induced hypopituitarism in adult\u2010onset brain tumour (<jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content>) survivors, in part the consequence of the limited survival of many of these individuals. We aim to characterize the pituitary\u2010related outcomes following cranial radiotherapy (<jats:styled-content style=\"fixed-case\">cXRT<\/jats:styled-content>) for adult\u2010onset primary nonpituitary brain tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We retrospectively analysed longitudinal data of patients with <jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content> who received <jats:styled-content style=\"fixed-case\">cXRT<\/jats:styled-content> within a tertiary cancer referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 107 adults (age 40\u00b70\u00a0\u00b1\u00a013\u00b71\u00a0years) followed for a median duration of 8\u00a0years following <jats:styled-content style=\"fixed-case\">cXRT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Prevalence of radiotherapy\u2010induced hypopituitarism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>94\u00b74% received fractionated photon radiotherapy (median dose 54\u00a0Gy), while the remaining patients received proton beam or stereotactic radiotherapy. 88\u00b78% of patients developed hypopituitarism during follow\u2010up. The frequency of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>, gonadotrophin, <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> deficiencies was 86\u00b79% (severe <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> 64\u00b75%, partial <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> 22\u00b74%), 34\u00b76%, 23\u00b74% and 11\u00b72%, respectively. <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> deficiency was clinically significant, necessitating glucocorticoid replacement, in only 10\u00b73% of cases. Hyperprolactinaemia developed in 15% of patients, which was persistent in only 50% of cases. Multiple pituitary hormone deficiencies were present in 47\u00b77% of patients, encountered more frequently in patients with tumours in proximity to the sella. Longitudinal data analysis revealed accumulation of hormone deficits throughout the follow\u2010up period, with incidence of all pituitary hormone deficiencies almost doubling between years 2 and 7 of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pituitary dysfunction in <jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content> survivors following <jats:styled-content style=\"fixed-case\">cXRT<\/jats:styled-content> is a common, evolving, time\u2010dependent phenomenon. It is important that deficits are identified early and replacement therapies introduced to optimize quality of life in these individuals, where prognosis is often guarded.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12969","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T14:12:44Z","timestamp":1445868764000},"page":"372-379","source":"Crossref","is-referenced-by-count":69,"title":["Pituitary dysfunction following cranial radiotherapy for adult\u2010onset nonpituitary brain tumours"],"prefix":"10.1111","volume":"84","author":[{"given":"Nikolaos","family":"Kyriakakis","sequence":"first","affiliation":[{"name":"Department of Endocrinology Leeds Centre for Diabetes &amp; Endocrinology St James's University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Leeds Centre for Diabetes &amp; Endocrinology St James's University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve M.","family":"Orme","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Leeds Centre for Diabetes &amp; Endocrinology St James's University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Gerrard","sequence":"additional","affiliation":[{"name":"Clinical Oncology Leeds Cancer Centre St James's University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hatfield","sequence":"additional","affiliation":[{"name":"Clinical Oncology Leeds Cancer Centre St James's University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel","family":"Loughrey","sequence":"additional","affiliation":[{"name":"Clinical Oncology Leeds Cancer Centre St James's University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C.","family":"Short","sequence":"additional","affiliation":[{"name":"Clinical Oncology Leeds Cancer Centre St James's University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Leeds Centre for Diabetes &amp; 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