{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:11:23Z","timestamp":1757779883901},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>The objective of this study was to evaluate symptoms of thyrotoxicosis, bone turnover, bone mineral density (BMD<\/jats:styled-content>) and occult atrial fibrillation (AF<\/jats:styled-content>) in women \u226565 years with mild endogenous subclinical hyperthyroidism (SCH<\/jats:styled-content>).<\/jats:p><\/jats:sec>Design<\/jats:title>Cross\u2010sectional and case\u2013control study.<\/jats:p><\/jats:sec>Patients<\/jats:title>Signs and symptoms of thyrotoxicosis, serum carboxyterminal telopeptide (CT<\/jats:styled-content>x) and procollagen type I N\u2010terminal propeptide (PINP<\/jats:styled-content>), BMD<\/jats:styled-content>, resting electrocardiogram (ECG<\/jats:styled-content>) and 72\u2010h ECG<\/jats:styled-content> monitoring were evaluated in 180 women \u226565 years, including 90 with mild SCH<\/jats:styled-content> (TSH<\/jats:styled-content> between 0\u00b71 and 0\u00b74 mIU\/l) and 90 euthyroid controls matched for age and body mass index.<\/jats:p><\/jats:sec>Results<\/jats:title>Symptom Rating Scale scores did not differ between patients and controls. None of the patients with SCH<\/jats:styled-content> scored 20 points, a score compatible with clinical thyrotoxicosis. Eighty patients with SCH<\/jats:styled-content> (89%) obtained seven or fewer points, a score compatible with euthyroidism. No difference in serum CT<\/jats:styled-content>x or PINP<\/jats:styled-content> concentrations was observed between patients and controls. There was also no correlation between these markers and TSH<\/jats:styled-content>, free T4 or total T3 levels. Finally, no difference in femoral neck or lumbar spine BMD<\/jats:styled-content> was observed between patients with SCH<\/jats:styled-content> and controls. Three patients with SCH<\/jats:styled-content> (3\u00b73%) and two euthyroid women (2\u00b72%) had known AF<\/jats:styled-content> or AF<\/jats:styled-content> in the resting ECG<\/jats:styled-content>. ECG<\/jats:styled-content> monitoring for 72 h revealed episodes of occult AF<\/jats:styled-content> in 1\/87 patients with SCH<\/jats:styled-content> and in 1\/88 euthyroid women (1\u00b71%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Mild endogenous SCH<\/jats:styled-content> (TSH<\/jats:styled-content> between 0\u00b71 and 0\u00b74 mIU\/l) was not associated with symptoms of thyrotoxicosis, altered bone metabolism or a higher prevalence of occult AF<\/jats:styled-content> in women \u226565 years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12979","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T16:04:42Z","timestamp":1448035482000},"page":"132-136","source":"Crossref","is-referenced-by-count":13,"title":["Symptoms of thyrotoxicosis, bone metabolism and occult atrial fibrillation in older women with mild endogenous subclinical hyperthyroidism"],"prefix":"10.1111","volume":"85","author":[{"given":"Pedro 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