{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:08:00Z","timestamp":1772492880420,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81130016"],"award-info":[{"award-number":["81130016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14ZR1425600"],"award-info":[{"award-number":["14ZR1425600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies have found that mild secondary hyperparathyroidism might be another clinical feature of patients with primary aldosteronims (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>), but whether serum parathyroid hormone level (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) is correlated with subtypes of <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and what contributes to the elevated <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> level remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To illustrate the changes of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and to partly explain the mechanism of how the effects of aldosterone regulating the secretion of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled a total of 120 patients with primary hypertension (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) and 242 patients with <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>, which included 89 <jats:styled-content style=\"fixed-case\">APA<\/jats:styled-content>s (aldosterone\u2010producing adenoma), 119 <jats:styled-content style=\"fixed-case\">IHA<\/jats:styled-content>s (idiopathic hyperaldosteronism) and 34 <jats:styled-content style=\"fixed-case\">UAH<\/jats:styled-content>s (unilateral adrenal hyperplasia). The plasma levels of aldosterone, renin activity, parathyroid hormone and markers associated with calcium metabolism were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found serum <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> level was significantly elevated in patients with <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> compared with primary hypertension [9\u00b70 (6\u00b76, 11\u00b77) <jats:italic>vs<\/jats:italic> 5\u00b77 (4\u00b74, 7\u00b70)] pmol\/l, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001]. However, no difference was found between the three <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> subtypes (<jats:italic>P<\/jats:italic> &gt; 0\u00b705). Stepwise multiple regression analysis showed that in patients with <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>, serum levels of K<jats:sup>+<\/jats:sup> and Ca<jats:sup>2+<\/jats:sup> were independently associated with serum <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> level. More importantly, elevated <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> level could be corrected either by unilateral adrenalectomy [9\u00b79 (7\u00b75, 12\u00b78) <jats:italic>vs<\/jats:italic> 5\u00b72 (4\u00b74, 7\u00b70) pmol\/l, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001] or mineralocorticoid receptor (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) antagonists treatment [11\u00b77 (9\u00b71, 13\u00b74) <jats:italic>vs<\/jats:italic> 6\u00b73 (5\u00b71, 7\u00b78) pmol\/l, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> level is elevated in <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> patients and irrelevant with subtypes of <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>. Serum K<jats:sup>+<\/jats:sup> and serum Ca<jats:sup>2+<\/jats:sup> level are main factors influence the plasma <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> level in <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> patients. After medical or surgical treatment, <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels return to normal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12981","type":"journal-article","created":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T11:42:48Z","timestamp":1448106168000},"page":"267-274","source":"Crossref","is-referenced-by-count":18,"title":["Factors affecting parathyroid hormone levels in different types of primary aldosteronism"],"prefix":"10.1111","volume":"85","author":[{"given":"Yiran","family":"Jiang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory for Endocrine Tumours Shanghai Clinical Centre for Endocrine and Metabolic Diseases and Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry Ruijin Hospital School of Medicine Shanghai Jiaotong University Shanghai 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Shanghai Clinical Centre for Endocrine and Metabolic Diseases and Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry Ruijin Hospital School of Medicine Shanghai Jiaotong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Endocrine Tumours Shanghai Clinical Centre for Endocrine and Metabolic Diseases and Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry Ruijin Hospital School of Medicine Shanghai Jiaotong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Endocrine Tumours Shanghai Clinical Centre for Endocrine and Metabolic Diseases and Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry Ruijin Hospital School of Medicine Shanghai 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