{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:01:54Z","timestamp":1771002114898,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001105"],"award-info":[{"award-number":["UL1TR001105"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Polycystic ovarian syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) is estimated to affect up to 20% of women. <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> is associated with insulin resistance and cardiovascular (<jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>) risk factors. We aimed to evaluate the impact of race\/ethnicity on the prevalence of <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> risk factors and subclinical predictors of <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional analysis of data collected by the Dallas Heart Study, an urban, population\u2010based cohort oversampled for blacks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A previously described cohort of women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and control subjects of the same racial\/ethnic group, matched for age and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Hormonal and clinical measures associated with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 117 women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and 204 controls. Women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> had significant differences across racial\/ethnic groups in the prevalence of hypertension, hypercholesterolaemia, hypertriglyceridaemia and impaired fasting glucose (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). Controls showed significant racial\/ethnic differences in the prevalence of hypertension and impaired fasting glucose (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). The odds of hypertension were significantly greater among women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> than controls after adjusting for race\/ethnicity (odds ratio, 1\u00b750 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1\u00b703\u20132\u00b730]; <jats:italic>P<\/jats:italic> = 0\u00b704). However, we did not see an interaction of race\/ethnicity that significantly changed <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> risk factor prevalence between <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and controls. In addition, subclinical measures of <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> disease were not different between women with <jats:styled-content style=\"fixed-case\">PCOS <\/jats:styled-content><jats:italic>vs<\/jats:italic> controls, even among hypertensive women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Race\/ethnicity affects the prevalence of <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> risk factors for women with and without <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. However, race\/ethnicity does not interact with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> to additionally increase <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> risk factor prevalence or subclinical <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12986","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T07:25:22Z","timestamp":1448522722000},"page":"92-99","source":"Crossref","is-referenced-by-count":37,"title":["Influence of race\/ethnicity on cardiovascular risk factors in polycystic ovary syndrome, the Dallas Heart Study"],"prefix":"10.1111","volume":"85","author":[{"given":"Alice Y.","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism, Diabetes and Nutrition Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Scientific Publications Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colby","family":"Ayers","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Auchus","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Diabetes, and Endocrinology University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032046"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep399"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des232"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03907.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2724"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2350"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0229"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02256.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1191"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.126650"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.10.1462"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91779-A"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.08.027"},{"key":"e_1_2_7_15_1","first-page":"143","article-title":"Racial and ethnic differences in cardiovascular disease risk factors: a systematic review","volume":"17","author":"Kurian A.K.","year":"2007","journal-title":"Ethnicity and Disease"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.5.586"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2430"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.02.058"},{"key":"e_1_2_7_19_1","unstructured":"Centers for Disease Control and Prevention.National health and nutrition examination survey III interviewer's manual [Interent][updated 1993 Jun; cited 2015 Feb 13]. 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